PMID- 11900248
OWN - NLM
STAT- MEDLINE
DCOM- 20020402
LR  - 20220321
IS  - 1474-175X (Print)
IS  - 1474-175X (Linking)
VI  - 1
IP  - 1
DP  - 2001 Oct
TI  - Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2.
PG  - 11-21
AB  - Population-based studies have established that long-term intake of non-steroidal 
      anti-inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity 
      of cyclooxygenase (COX), reduces the relative risk for developing colorectal 
      cancer. These studies led to the identification of a molecular target, COX-2, 
      that is involved in tumour promotion during colorectal cancer progression. Recent 
      studies in humans indicate that therapy with specific COX-2 inhibitors might be 
      an effective approach to colorectal cancer prevention and treatment.
FAU - Gupta, R A
AU  - Gupta RA
AD  - Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 
      37232-2279, USA.
FAU - Dubois, R N
AU  - Dubois RN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Nat Rev Cancer
JT  - Nature reviews. Cancer
JID - 101124168
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Cyclooxygenase 2 Inhibitors)
RN  - 0 (Cyclooxygenase Inhibitors)
RN  - 0 (Isoenzymes)
RN  - 0 (Membrane Proteins)
RN  - 0 (Prostaglandins)
RN  - 0 (Receptors, Prostaglandin E)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - EC 1.14.99.1 (PTGS2 protein, human)
RN  - EC 1.14.99.1 (Prostaglandin-Endoperoxide Synthases)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
MH  - Colorectal Neoplasms/drug therapy/enzymology/*prevention & control
MH  - Cyclooxygenase 2
MH  - Cyclooxygenase 2 Inhibitors
MH  - Cyclooxygenase Inhibitors/*therapeutic use
MH  - Disease Models, Animal
MH  - Humans
MH  - Isoenzymes/*antagonists & inhibitors/physiology
MH  - Membrane Proteins
MH  - Prostaglandin-Endoperoxide Synthases/physiology
MH  - Prostaglandins/biosynthesis
MH  - Receptors, Prostaglandin E/physiology
RF  - 127
EDAT- 2002/03/20 10:00
MHDA- 2002/04/03 10:01
CRDT- 2002/03/20 10:00
PHST- 2002/03/20 10:00 [pubmed]
PHST- 2002/04/03 10:01 [medline]
PHST- 2002/03/20 10:00 [entrez]
AID - 10.1038/35094017 [doi]
PST - ppublish
SO  - Nat Rev Cancer. 2001 Oct;1(1):11-21. doi: 10.1038/35094017.