PMID- 11905807
OWN - NLM
STAT- MEDLINE
DCOM- 20020416
LR  - 20220310
IS  - 1474-175X (Print)
IS  - 1474-175X (Linking)
VI  - 1
IP  - 2
DP  - 2001 Nov
TI  - Two genetic hits (more or less) to cancer.
PG  - 157-62
AB  - Most cancers have many chromosomal abnormalities, both in number and in 
      structure, whereas some show only a single aberration. In the era before 
      molecular biology, cancer researchers, studying both human and animal cancers, 
      proposed that a small number of events was needed for carcinogenesis. Evidence 
      from the recent molecular era also indicates that cancers can arise from small 
      numbers of events that affect common cell birth and death processes.
FAU - Knudson, A G
AU  - Knudson AG
AD  - Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA. 
      ag_knudson@fccc.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Nat Rev Cancer
JT  - Nature reviews. Cancer
JID - 101124168
RN  - 0 (Carcinogens)
RN  - 0 (Mutagens)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Aneuploidy
MH  - Animals
MH  - Carcinogens/adverse effects
MH  - Cell Transformation, Neoplastic/*genetics
MH  - Child
MH  - Chromosome Aberrations
MH  - Female
MH  - Forecasting
MH  - Genes, Retinoblastoma
MH  - Genes, Tumor Suppressor
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Kinetics
MH  - Male
MH  - *Models, Genetic
MH  - Mutagens/adverse effects
MH  - Mutation
MH  - Neoplasms/epidemiology/genetics
MH  - Oncogenes
MH  - Retinoblastoma/epidemiology/genetics
RF  - 55
EDAT- 2002/03/22 10:00
MHDA- 2002/04/17 10:01
CRDT- 2002/03/22 10:00
PHST- 2002/03/22 10:00 [pubmed]
PHST- 2002/04/17 10:01 [medline]
PHST- 2002/03/22 10:00 [entrez]
AID - 10.1038/35101031 [doi]
PST - ppublish
SO  - Nat Rev Cancer. 2001 Nov;1(2):157-62. doi: 10.1038/35101031.