PMID- 11990853
OWN - NLM
STAT- MEDLINE
DCOM- 20020524
LR  - 20240109
IS  - 1474-175X (Print)
IS  - 1474-175X (Linking)
VI  - 2
IP  - 3
DP  - 2002 Mar
TI  - New functions for the matrix metalloproteinases in cancer progression.
PG  - 161-74
AB  - Matrix metalloproteinases (MMPs) have long been associated with cancer-cell 
      invasion and metastasis. This provided the rationale for clinical trials of MMP 
      inhibitors, unfortunately with disappointing results. We now know, however, that 
      the MMPs have functions other than promotion of invasion, have substrates other 
      than components of the extracellular matrix, and that they function before 
      invasion in the development of cancer. With this knowledge in hand, can we 
      rethink the use of MMP inhibitors in the clinic?
FAU - Egeblad, Mikala
AU  - Egeblad M
AD  - Department of Anatomy, University of California at San Francisco, 94143-0452, 
      USA. egeblad@itsa.ucsf.edu
FAU - Werb, Zena
AU  - Werb Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Nat Rev Cancer
JT  - Nature reviews. Cancer
JID - 101124168
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - *Cell Transformation, Neoplastic
MH  - Disease Progression
MH  - Humans
MH  - Matrix Metalloproteinases/*metabolism
MH  - Neoplasms/enzymology/pathology/*physiopathology
RF  - 159
EDAT- 2002/05/07 10:00
MHDA- 2002/05/25 10:01
CRDT- 2002/05/07 10:00
PHST- 2002/05/07 10:00 [pubmed]
PHST- 2002/05/25 10:01 [medline]
PHST- 2002/05/07 10:00 [entrez]
AID - 10.1038/nrc745 [doi]
PST - ppublish
SO  - Nat Rev Cancer. 2002 Mar;2(3):161-74. doi: 10.1038/nrc745.