PMID- 12067969
OWN - NLM
STAT- MEDLINE
DCOM- 20020719
LR  - 20220318
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 62
IP  - 12
DP  - 2002 Jun 15
TI  - Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor 
      invasion.
PG  - 3335-9
AB  - The gene most commonly altered in human glioblastomas is the epidermalgrowth 
      factor receptor (EGFR). We profiled transcripts induced by mutantEGFR to better 
      understand its role in tumor progression. The pattern found suggested enhanced 
      tumor invasion. The highly induced genes included extracellular matrix 
      components, metalloproteases, and a serine protease. We confirmed that mutant 
      EGFR did make glioblastoma cells both more motile and invasive using in vitro 
      assays. Furthermore, inhibitors of EGFR (OSI-774 and Tyrphostin AG1478) 
      selectively down-regulated these molecular effectors in glioblastoma cells, 
      eliminating enhanced invasion.
FAU - Lal, Anita
AU  - Lal A
AD  - Department of Pathology, Duke University Medical Center, Durham, North Carolina 
      27710, USA.
FAU - Glazer, Chad A
AU  - Glazer CA
FAU - Martinson, Holly M
AU  - Martinson HM
FAU - Friedman, Henry S
AU  - Friedman HS
FAU - Archer, Gary E
AU  - Archer GE
FAU - Sampson, John H
AU  - Sampson JH
FAU - Riggins, Gregory J
AU  - Riggins GJ
LA  - eng
GR  - CA88128/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Quinazolines)
RN  - 0 (Tyrphostins)
RN  - 0 (epidermal growth factor receptor VIII)
RN  - 170449-18-0 (RTKI cpd)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 3.4.21.- (Serine Endopeptidases)
RN  - EC 3.4.24.- (Metalloendopeptidases)
SB  - IM
MH  - Animals
MH  - Enzyme Inhibitors/pharmacology
MH  - ErbB Receptors/antagonists & inhibitors/biosynthesis/genetics/*physiology
MH  - Extracellular Matrix Proteins/biosynthesis/*genetics
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation, Neoplastic/drug effects
MH  - Glioblastoma/*genetics/metabolism/pathology
MH  - Humans
MH  - Metalloendopeptidases/biosynthesis/genetics
MH  - Mice
MH  - Mice, Nude
MH  - Neoplasm Invasiveness
MH  - Quinazolines
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Serine Endopeptidases/biosynthesis/genetics
MH  - Transfection
MH  - Tumor Cells, Cultured
MH  - Tyrphostins/pharmacology
MH  - Up-Regulation
EDAT- 2002/06/18 10:00
MHDA- 2002/07/20 10:01
CRDT- 2002/06/18 10:00
PHST- 2002/06/18 10:00 [pubmed]
PHST- 2002/07/20 10:01 [medline]
PHST- 2002/06/18 10:00 [entrez]
PST - ppublish
SO  - Cancer Res. 2002 Jun 15;62(12):3335-9.