PMID- 12067971
OWN - NLM
STAT- MEDLINE
DCOM- 20020719
LR  - 20210103
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 62
IP  - 12
DP  - 2002 Jun 15
TI  - Human cytomegalovirus infection and expression in human malignant glioma.
PG  - 3347-50
AB  - Malignant gliomas are the most common primary brain tumors in adults, have no 
      known etiology, and are generally rapidly fatal despite current therapies. Human 
      cytomegalovirus (HCMV) is beta-herpesvirus trophic for glial cells that 
      persistently infects 50-90% of the adult human population. HCMV can be 
      reactivated under conditions of inflammation and immunosuppression, and HCMV gene 
      products can dysregulate multiple cellular pathways involved in oncogenesis. Here 
      we show that a high percentage of malignant gliomas are infected by HCMV and 
      multiple HCMV gene products are expressed in these tumors. These data are the 
      first to show an association between HCMV and malignant gliomas and suggest that 
      HCMV may play an active role in glioma pathogenesis.
FAU - Cobbs, Charles S
AU  - Cobbs CS
AD  - Surgical Service, Veterans Affairs Medical Center, Birmingham, Alabama, USA. 
      cscobbs@uabmc.edu
FAU - Harkins, Lualhati
AU  - Harkins L
FAU - Samanta, Minu
AU  - Samanta M
FAU - Gillespie, G Yancey
AU  - Gillespie GY
FAU - Bharara, Suman
AU  - Bharara S
FAU - King, Peter H
AU  - King PH
FAU - Nabors, L Burt
AU  - Nabors LB
FAU - Cobbs, C Glenn
AU  - Cobbs CG
FAU - Britt, William J
AU  - Britt WJ
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (DNA, Viral)
RN  - 0 (IE1 protein, cytomegalovirus)
RN  - 0 (Immediate-Early Proteins)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Astrocytoma/metabolism/pathology/virology
MH  - Brain Neoplasms/metabolism/pathology/*virology
MH  - Cytomegalovirus/*genetics/metabolism
MH  - Cytomegalovirus Infections/*complications/metabolism
MH  - DNA, Viral/genetics/metabolism
MH  - Gene Expression
MH  - Genes, Viral
MH  - Glioma/metabolism/pathology/*virology
MH  - Humans
MH  - Immediate-Early Proteins/biosynthesis/genetics
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Meningioma/metabolism/pathology/virology
MH  - *Viral Proteins
EDAT- 2002/06/18 10:00
MHDA- 2002/07/20 10:01
CRDT- 2002/06/18 10:00
PHST- 2002/06/18 10:00 [pubmed]
PHST- 2002/07/20 10:01 [medline]
PHST- 2002/06/18 10:00 [entrez]
PST - ppublish
SO  - Cancer Res. 2002 Jun 15;62(12):3347-50.