PMID- 12379912
OWN - NLM
STAT- MEDLINE
DCOM- 20030114
LR  - 20220830
IS  - 0894-1491 (Print)
IS  - 0894-1491 (Linking)
VI  - 40
IP  - 2
DP  - 2002 Nov
TI  - Microglia in brain tumors.
PG  - 252-259
LID - 10.1002/glia.10147 [doi]
AB  - Microglia have long been ignored by neurooncologists. This has changed with the 
      realization that microglial cells not only occur within and around brain tumors 
      but also contribute significantly to the actual tumor mass, notably in astrocytic 
      gliomas. In addition, it has been speculated that microglia could play a role in 
      the defense against neoplasms of the nervous system. However, the biological 
      success of these tumors, i.e., their highly malignant behavior, indicates that 
      natural microglial defense mechanisms do not function properly in astrocytomas. 
      In fact, there is evidence that microglial behavior is controlled by tumor cells, 
      supporting their growth and infiltration. This unexpected "Achilles heel" of 
      microglial immune defense illustrates the risk of generalizing on the basis of a 
      single aspect of microglial biology. Microglia are highly plastic cells, capable 
      of exerting cytotoxic functions under conditions of CNS infections, but not 
      necessarily during glioma progression. Thus, the suggestion that microglial 
      activation through stimulation by cytokines (e.g., interferon-gamma) will benefit 
      patients with brain tumors could prove fatally wrong. Therapeutic recruitment of 
      microglia to treat such diffusely infiltrative brain tumors as astrocytic gliomas 
      must be considered premature.
CI  - Copyright 2002 Wiley-Liss, Inc.
FAU - Graeber, Manuel B
AU  - Graeber MB
AD  - Department of Neuropathology, Faculty of Medicine, Imperial College, London, 
      United Kingdom.
FAU - Scheithauer, Bernd W
AU  - Scheithauer BW
AD  - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, 
      Minnesota.
FAU - Kreutzberg, Georg W
AU  - Kreutzberg GW
AD  - Department of Neuromorphology, Max-Planck-Institute of Neurobiology, Martinsried, 
      Germany.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Glia
JT  - Glia
JID - 8806785
SB  - IM
MH  - Antigen Presentation/immunology
MH  - Astrocytoma/*immunology/pathology/therapy
MH  - Brain Neoplasms/*immunology/pathology/therapy
MH  - Cell Count
MH  - Cell Division
MH  - Cell Lineage
MH  - Glioma/*immunology/pathology/therapy
MH  - Humans
MH  - Immunotherapy
MH  - Macrophages/pathology
MH  - Microglia/*immunology/pathology
MH  - Neoplasm Invasiveness/immunology
MH  - Oligodendroglioma/*immunology/pathology/therapy
RF  - 61
EDAT- 2002/10/16 04:00
MHDA- 2003/01/15 04:00
CRDT- 2002/10/16 04:00
PHST- 2002/10/16 04:00 [pubmed]
PHST- 2003/01/15 04:00 [medline]
PHST- 2002/10/16 04:00 [entrez]
AID - 10.1002/glia.10147 [doi]
PST - ppublish
SO  - Glia. 2002 Nov;40(2):252-259. doi: 10.1002/glia.10147.