PMID- 12479803
OWN - NLM
STAT- MEDLINE
DCOM- 20030110
LR  - 20191106
IS  - 1534-5807 (Print)
IS  - 1534-5807 (Linking)
VI  - 3
IP  - 6
DP  - 2002 Dec
TI  - The Jak/STAT pathway in model organisms: emerging roles in cell movement.
PG  - 765-78
AB  - The JAK/STAT pathway was originally identified in mammals. Studies of this 
      pathway in the mouse have revealed that JAK/STAT signaling plays a central role 
      during hematopoeisis and other developmental processes. The role of JAK/STAT 
      signaling in blood appears to be conserved throughout evolution, as it is also 
      required during fly hematopoeisis. Studies in Dictyostelium, Drosophila, and 
      zebrafish have shown that the JAK/STAT pathway is also required in an unusually 
      broad set of developmental decisions, including cell proliferation, cell fate 
      determination, cell migration, planar polarity, convergent extension, and 
      immunity. There is increasing evidence that the versatility of this pathway 
      relies on its cooperation with other signal transduction pathways. In this 
      review, we discuss the components of the JAK/STAT pathway in model organisms and 
      what is known about its requirement in cellular and developmental processes. In 
      particular, we emphasize recent insights into the role that this pathway plays in 
      the control of cell movement.
FAU - Hou, Steven X
AU  - Hou SX
AD  - The Laboratory of Immunobiology, National Cancer Institute at Frederick, Building 
      560, Room 12-70, MD 21702, USA. shou@mail.ncifcrf.gov
FAU - Zheng, Zhiyu
AU  - Zheng Z
FAU - Chen, Xiu
AU  - Chen X
FAU - Perrimon, Norbert
AU  - Perrimon N
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - Dev Cell
JT  - Developmental cell
JID - 101120028
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (STAT1 Transcription Factor)
RN  - 0 (STAT1 protein, human)
RN  - 0 (Trans-Activators)
RN  - 0 (Zebrafish Proteins)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.2 (JAK1 protein, human)
RN  - EC 2.7.10.2 (Jak1 protein, mouse)
RN  - EC 2.7.10.2 (Janus Kinase 1)
RN  - EC 2.7.10.2 (jak1 protein, zebrafish)
SB  - IM
MH  - Animals
MH  - Cell Division/physiology
MH  - Cell Lineage/physiology
MH  - Cell Movement/*physiology
MH  - Cell Polarity/physiology
MH  - DNA-Binding Proteins/*metabolism
MH  - Eukaryotic Cells/cytology/*metabolism
MH  - Hematopoiesis/physiology
MH  - Humans
MH  - Janus Kinase 1
MH  - Models, Animal
MH  - Protein-Tyrosine Kinases/*metabolism
MH  - STAT1 Transcription Factor
MH  - Signal Transduction/*physiology
MH  - Trans-Activators/*metabolism
MH  - Zebrafish Proteins
RF  - 105
EDAT- 2002/12/14 04:00
MHDA- 2003/01/11 04:00
CRDT- 2002/12/14 04:00
PHST- 2002/12/14 04:00 [pubmed]
PHST- 2003/01/11 04:00 [medline]
PHST- 2002/12/14 04:00 [entrez]
AID - S1534-5807(02)00376-3 [pii]
AID - 10.1016/s1534-5807(02)00376-3 [doi]
PST - ppublish
SO  - Dev Cell. 2002 Dec;3(6):765-78. doi: 10.1016/s1534-5807(02)00376-3.