PMID- 12522256
OWN - NLM
STAT- MEDLINE
DCOM- 20030303
LR  - 20220409
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 299
IP  - 5609
DP  - 2003 Feb 14
TI  - Control of regulatory T cell development by the transcription factor Foxp3.
PG  - 1057-61
AB  - Regulatory T cells engage in the maintenance of immunological self-tolerance by 
      actively suppressing self-reactive lymphocytes. Little is known, however, about 
      the molecular mechanism of their development. Here we show that Foxp3, which 
      encodes a transcription factor that is genetically defective in an autoimmune and 
      inflammatory syndrome in humans and mice, is specifically expressed in naturally 
      arising CD4+ regulatory T cells. Furthermore, retroviral gene transfer of Foxp3 
      converts naive T cells toward a regulatory T cell phenotype similar to that of 
      naturally occurring CD4+ regulatory T cells. Thus, Foxp3 is a key regulatory gene 
      for the development of regulatory T cells.
FAU - Hori, Shohei
AU  - Hori S
AD  - Laboratory of Immunopathology, Research Center for Allergy and Immunology, 
      Institute for Physical and Chemical Research, Yokohama 230-0045, Japan.
FAU - Nomura, Takashi
AU  - Nomura T
FAU - Sakaguchi, Shimon
AU  - Sakaguchi S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20030109
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Antigens, CD)
RN  - 0 (Cytokines)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxp3 protein, mouse)
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - 0 (Receptors, Interleukin-2)
RN  - 0 (Recombinant Fusion Proteins)
SB  - IM
CIN - Science. 2003 Feb 14;299(5609):1030-1. PMID: 12586934
MH  - Animals
MH  - Antigens, CD/analysis
MH  - Autoimmune Diseases/immunology/prevention & control
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Cytokines/biosynthesis
MH  - DNA-Binding Proteins/genetics/*metabolism
MH  - Forkhead Transcription Factors
MH  - Gastritis/immunology/prevention & control
MH  - *Immune Tolerance
MH  - Inflammatory Bowel Diseases/immunology/prevention & control
MH  - Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, SCID
MH  - Mice, Transgenic
MH  - Mutation
MH  - Receptors, Antigen, T-Cell/immunology
MH  - Receptors, Interleukin-2/analysis
MH  - Recombinant Fusion Proteins/metabolism
MH  - Self Tolerance
MH  - T-Lymphocyte Subsets/cytology/immunology
MH  - T-Lymphocytes/immunology
MH  - T-Lymphocytes, Regulatory/*immunology/*metabolism
MH  - Thymus Gland/cytology/metabolism
MH  - Transduction, Genetic
EDAT- 2003/01/11 04:00
MHDA- 2003/03/04 04:00
CRDT- 2003/01/11 04:00
PHST- 2003/01/11 04:00 [pubmed]
PHST- 2003/03/04 04:00 [medline]
PHST- 2003/01/11 04:00 [entrez]
AID - 1079490 [pii]
AID - 10.1126/science.1079490 [doi]
PST - ppublish
SO  - Science. 2003 Feb 14;299(5609):1057-61. doi: 10.1126/science.1079490. Epub 2003 
      Jan 9.