PMID- 12552021
OWN - NLM
STAT- MEDLINE
DCOM- 20030314
LR  - 20190508
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 77
IP  - 4
DP  - 2003 Feb
TI  - Kinetics of virus-specific CD8+ -T-cell expansion and trafficking following 
      central nervous system infection.
PG  - 2775-8
AB  - CD8+ T cells control acute infection of the central nervous system (CNS) by 
      neurotropic mouse hepatitis virus but do not suffice to achieve sterile immunity. 
      To determine the lag between T-cell priming and optimal activity within the CNS, 
      the accumulation of virus-specific CD8+ T cells in the CNS relative to that in 
      peripheral lymphoid organs was assessed by using gamma interferon-specific 
      ELISPOT assays and class I tetramer staining. Virus-specific CD8+ T cells were 
      first detected in the cervical lymph nodes. Expansion in the spleen was delayed 
      and less pronounced but also preceded accumulation in the CNS. The data further 
      suggest peripheral acquisition of cytolytic function, thus enhancing CD8+ -T-cell 
      effector function upon cognate antigen recognition in the CNS.
FAU - Marten, Norman W
AU  - Marten NW
AD  - Department of Pathology, Keck School of Medicine, University of Southern 
      California, 1333 San Pablo Street, Los Angeles, CA 90033, USA.
FAU - Stohlman, Stephen A
AU  - Stohlman SA
FAU - Zhou, Jiehao
AU  - Zhou J
FAU - Bergmann, Cornelia C
AU  - Bergmann CC
LA  - eng
GR  - P01 NS018146/NS/NINDS NIH HHS/United States
GR  - NS 18146/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Brain/immunology
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Central Nervous System Viral Diseases/*immunology/virology
MH  - Coronavirus Infections/immunology
MH  - Interferon-gamma/metabolism
MH  - Kinetics
MH  - Lymph Nodes/immunology
MH  - Lymphocyte Activation/*immunology
MH  - Mice
MH  - Murine hepatitis virus/*immunology
MH  - Spleen/immunology
PMC - PMC141092
EDAT- 2003/01/29 04:00
MHDA- 2003/03/15 04:00
PMCR- 2003/02/01
CRDT- 2003/01/29 04:00
PHST- 2003/01/29 04:00 [pubmed]
PHST- 2003/03/15 04:00 [medline]
PHST- 2003/01/29 04:00 [entrez]
PHST- 2003/02/01 00:00 [pmc-release]
AID - 1553 [pii]
AID - 10.1128/jvi.77.4.2775-2778.2003 [doi]
PST - ppublish
SO  - J Virol. 2003 Feb;77(4):2775-8. doi: 10.1128/jvi.77.4.2775-2778.2003.