PMID- 12612581
OWN - NLM
STAT- MEDLINE
DCOM- 20030423
LR  - 20220409
IS  - 1529-2908 (Print)
IS  - 1529-2908 (Linking)
VI  - 4
IP  - 4
DP  - 2003 Apr
TI  - An essential role for Scurfin in CD4+CD25+ T regulatory cells.
PG  - 337-42
AB  - The molecular properties that characterize CD4+CD25+ regulatory T cells (TR 
      cells) remain elusive. Absence of the transcription factor Scurfin (also known as 
      forkhead box P3 and encoded by Foxp3) causes a rapidly fatal lymphoproliferative 
      disease, similar to that seen in mice lacking cytolytic T lymphocyte-associated 
      antigen 4 (CTLA-4). Here we show that Foxp3 is highly expressed by T(R) cells and 
      is associated with T(R) cell activity and phenotype. Scurfin-deficient mice lack 
      T(R) cells, whereas mice that overexpress Foxp3 possess more T(R) cells. In 
      Foxp3-overexpressing mice, both CD4+CD25- and CD4-CD8+ T cells show suppressive 
      activity and CD4+CD25- cells express glucocorticoid-induced tumor-necrosis factor 
      receptor-related (GITR) protein. The forced expression of Foxp3 also delays 
      disease in CTLA-4-/- mice, indicating that the Scurfin and CTLA-4 pathways may 
      intersect and providing further insight into the T(R) cell lineage.
FAU - Khattri, Roli
AU  - Khattri R
AD  - Celltech R&D Inc., 1631 220th Street SE, Bothell, Washington 98021, USA.
FAU - Cox, Tom
AU  - Cox T
FAU - Yasayko, Sue-Ann
AU  - Yasayko SA
FAU - Ramsdell, Fred
AU  - Ramsdell F
LA  - eng
PT  - Journal Article
DEP - 20030303
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation)
RN  - 0 (CTLA-4 Antigen)
RN  - 0 (CTLA4 protein, human)
RN  - 0 (Ctla4 protein, mouse)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxp3 protein, mouse)
RN  - 0 (Glucocorticoid-Induced TNFR-Related Protein)
RN  - 0 (Immunoconjugates)
RN  - 0 (Receptors, Interleukin-2)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (TNFRSF18 protein, human)
RN  - 0 (Tnfrsf18 protein, mouse)
RN  - 0 (Transforming Growth Factor beta)
RN  - 130068-27-8 (Interleukin-10)
RN  - 7D0YB67S97 (Abatacept)
SB  - IM
CIN - Nat Immunol. 2003 Apr;4(4):304-6. PMID: 12660726
MH  - Abatacept
MH  - Animals
MH  - Antigens, CD
MH  - Antigens, Differentiation/genetics/metabolism
MH  - CD4-Positive T-Lymphocytes/immunology/*metabolism
MH  - CTLA-4 Antigen
MH  - DNA-Binding Proteins/genetics/*immunology/*metabolism
MH  - Forkhead Transcription Factors
MH  - Glucocorticoid-Induced TNFR-Related Protein
MH  - *Immunoconjugates
MH  - Interleukin-10/metabolism
MH  - Mice
MH  - Mice, Transgenic
MH  - Receptors, Interleukin-2/immunology/*metabolism
MH  - Receptors, Nerve Growth Factor/metabolism
MH  - Receptors, Tumor Necrosis Factor/metabolism
MH  - Transforming Growth Factor beta/metabolism
EDAT- 2003/03/04 04:00
MHDA- 2003/04/24 05:00
CRDT- 2003/03/04 04:00
PHST- 2003/01/17 00:00 [received]
PHST- 2003/02/09 00:00 [accepted]
PHST- 2003/03/04 04:00 [pubmed]
PHST- 2003/04/24 05:00 [medline]
PHST- 2003/03/04 04:00 [entrez]
AID - ni909 [pii]
AID - 10.1038/ni909 [doi]
PST - ppublish
SO  - Nat Immunol. 2003 Apr;4(4):337-42. doi: 10.1038/ni909. Epub 2003 Mar 3.