PMID- 12675316
OWN - NLM
STAT- MEDLINE
DCOM- 20030430
LR  - 20190910
IS  - 0167-594X (Print)
IS  - 0167-594X (Linking)
VI  - 61
IP  - 3
DP  - 2003 Feb
TI  - Symptomatic spinal dissemination of malignant astrocytoma.
PG  - 227-35
AB  - OBJECT: Symptomatic spinal dissemination of malignant astrocytoma is rarely found 
      except at autopsy. This study evaluated the clinical incidence and 
      characteristics of spinal dissemination and the effect on outcome. PATIENTS AND 
      METHODS: Patients treated for primary malignant astrocytoma, including 33 with 
      anaplastic astrocytoma and 35 with glioblastoma, at our department between 1997 
      and 1999 were followed up until April 30, 2001. Head magnetic resonance (MR) 
      imaging of all patients was obtained every 2-3 months. Signs and symptoms of 
      leptomeningeal spread were checked at monthly outpatient examinations. Spinal MR 
      imaging was performed if any symptoms indicating spinal dissemination were found. 
      RESULTS: Median survival times of patients with anaplastic astrocytoma and 
      glioblastoma were 40.5 and 16.0 months, respectively. Seventeen patients (25%) 
      developed intracranial dissemination and 15 of these died. Six patients (8.8%), 
      one with anaplastic astrocytoma and five with glioblastoma, developed spinal 
      dissemination. All patients with spinal dissemination also had intracranial 
      dissemination. Five of the six patients died, despite systemic radiochemotherapy 
      in four patients. All patients died of extensive whole brain and spinal 
      dissemination or nodular mass enlargement at the upper cervical cord, not of 
      local massive tumor progression. CONCLUSIONS: Symptomatic spinal dissemination of 
      malignant astrocytoma is not so rare, and is the cause of death. The relatively 
      high incidence of symptomatic leptomeningeal dissemination must be considered in 
      the treatment of malignant astrocytomas.
FAU - Saito, Ryuta
AU  - Saito R
AD  - Department of Neurosurgery, Tohoku University Graduate School of Medicine, 
      Sendai, Japan.
FAU - Kumabe, Toshihiro
AU  - Kumabe T
FAU - Jokura, Hidefumi
AU  - Jokura H
FAU - Shirane, Reizo
AU  - Shirane R
FAU - Yoshimoto, Takashi
AU  - Yoshimoto T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Neurooncol
JT  - Journal of neuro-oncology
JID - 8309335
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Astrocytoma/*diagnosis/mortality/*secondary
MH  - Brain Neoplasms/*diagnosis/mortality
MH  - Female
MH  - Follow-Up Studies
MH  - Glioblastoma/diagnosis/*secondary
MH  - Humans
MH  - Japan
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Meningeal Neoplasms/diagnosis/mortality/*secondary
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Spinal Neoplasms/diagnosis/mortality/*secondary
MH  - Survival Rate
EDAT- 2003/04/05 05:00
MHDA- 2003/05/06 05:00
CRDT- 2003/04/05 05:00
PHST- 2003/04/05 05:00 [pubmed]
PHST- 2003/05/06 05:00 [medline]
PHST- 2003/04/05 05:00 [entrez]
AID - 10.1023/a:1022536828345 [doi]
PST - ppublish
SO  - J Neurooncol. 2003 Feb;61(3):227-35. doi: 10.1023/a:1022536828345.