PMID- 12697968
OWN - NLM
STAT- MEDLINE
DCOM- 20030507
LR  - 20171101
IS  - 0030-2414 (Print)
IS  - 0030-2414 (Linking)
VI  - 64
IP  - 3
DP  - 2003
TI  - Expression of vascular endothelial growth factor and angiogenesis in 
      gastrointestinal stromal tumor of the stomach.
PG  - 266-74
AB  - Vascular endothelial growth factor (VEGF) is associated with the malignant 
      potential of several types of carcinoma. The aim of this study was to elucidate 
      the clinical significance of VEGF expression in gastrointestinal stromal tumor 
      (GIST). METHODS: Specimens obtained from 53 patients who had underwent surgical 
      resection for GIST of the stomach were used in this study. Specimens were 
      examined immunohistochemically for VEGF expression and Ki-67 expression. Tumor 
      microvessel density (MVD) was determined immunohistochemically with anti-CD31 
      antibody, and was estimated by averaging the counts from three high-power fields 
      in the area showing the greatest neovascularization. RESULTS: VEGF expression was 
      detected in 14 (26.4%) of the 53 lesions and correlated significantly with tumor 
      size, liver metastasis, Ki-67 labeling index, and MVD. Prognosis was 
      significantly poorer than in patients with tumors expressing VEGF than in 
      patients with tumors lacking VEGF expression. Multiple logistic regression 
      analysis for 10-year survival showed VEGF expression and high mitotic rate to be 
      independent predictor of a poor outcome. CONCLUSIONS: Angiogenesis associated 
      with VEGF may play an important role in the progression of GIST. VEGF expression 
      may serve as an indicator of a poor prognosis.
CI  - Copyright 2003 S. Karger AG, Basel
FAU - Takahashi, Ryoji
AU  - Takahashi R
AD  - First Department of Internal Medicine, Hiroshima University School of Medicine, 
      1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
FAU - Tanaka, Shinji
AU  - Tanaka S
FAU - Kitadai, Yasuhiko
AU  - Kitadai Y
FAU - Sumii, Masaharu
AU  - Sumii M
FAU - Yoshihara, Masaharu
AU  - Yoshihara M
FAU - Haruma, Ken
AU  - Haruma K
FAU - Chayama, Kazuaki
AU  - Chayama K
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Oncology
JT  - Oncology
JID - 0135054
RN  - 0 (Endothelial Growth Factors)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Ki-67 Antigen)
RN  - 0 (Lymphokines)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Vascular Endothelial Growth Factors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Endothelial Growth Factors/*analysis
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Intercellular Signaling Peptides and Proteins/*analysis
MH  - Ki-67 Antigen/analysis
MH  - Logistic Models
MH  - Lymphokines/*analysis
MH  - Male
MH  - Microcirculation
MH  - Middle Aged
MH  - Mitotic Index
MH  - Multivariate Analysis
MH  - Neovascularization, Pathologic/*metabolism
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Stomach Neoplasms/*blood supply/*chemistry/pathology
MH  - *Stromal Cells
MH  - Survival Analysis
MH  - Vascular Endothelial Growth Factor A
MH  - Vascular Endothelial Growth Factors
EDAT- 2003/04/17 05:00
MHDA- 2003/05/08 05:00
CRDT- 2003/04/17 05:00
PHST- 2003/04/17 05:00 [pubmed]
PHST- 2003/05/08 05:00 [medline]
PHST- 2003/04/17 05:00 [entrez]
AID - 69316 [pii]
AID - 10.1159/000069316 [doi]
PST - ppublish
SO  - Oncology. 2003;64(3):266-74. doi: 10.1159/000069316.