PMID- 12776209
OWN - NLM
STAT- MEDLINE
DCOM- 20030710
LR  - 20200327
IS  - 1474-1733 (Print)
IS  - 1474-1741 (Electronic)
IS  - 1474-1733 (Linking)
VI  - 3
IP  - 6
DP  - 2003 Jun
TI  - Immune responses to RNA-virus infections of the CNS.
PG  - 493-502
AB  - A successful outcome for the host of virus infection of the central nervous 
      system (CNS) requires the elimination of the virus without damage to essential 
      non-renewable cells, such as neurons. As a result, inflammatory responses must be 
      tightly controlled, and many unique mechanisms seem to contribute to this 
      control. In addition to being important causes of human disease, RNA viruses that 
      infect the CNS provide useful models in which to study immune responses in the 
      CNS. Recent work has shown the importance of innate immune responses in the CNS 
      in controlling virus infection. And advances have been made in assessing the 
      relative roles of cytotoxic T cells, antibodies and cytokines in the clearance of 
      viruses from neurons, glial cells and meningeal cells.
FAU - Griffin, Diane E
AU  - Griffin DE
AD  - W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns 
      Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA. 
      dgriffin@jhsph.edu
LA  - eng
GR  - R01 NS038932/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Nat Rev Immunol
JT  - Nature reviews. Immunology
JID - 101124169
RN  - 0 (Antibodies, Viral)
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/immunology
MH  - Central Nervous System Infections/*immunology/virology
MH  - Cytokines/immunology
MH  - Disease Models, Animal
MH  - Humans
MH  - Immunity, Active
MH  - Immunity, Cellular
MH  - Immunity, Innate
MH  - Mice
MH  - Neurons/immunology/virology
MH  - RNA Virus Infections/*immunology
MH  - T-Lymphocytes, Cytotoxic/immunology
PMC - PMC7097089
EDAT- 2003/05/31 05:00
MHDA- 2003/07/11 05:00
PMCR- 2020/03/26
CRDT- 2003/05/31 05:00
PHST- 2003/05/31 05:00 [pubmed]
PHST- 2003/07/11 05:00 [medline]
PHST- 2003/05/31 05:00 [entrez]
PHST- 2020/03/26 00:00 [pmc-release]
AID - nri1105 [pii]
AID - BFnri1105 [pii]
AID - 10.1038/nri1105 [doi]
PST - ppublish
SO  - Nat Rev Immunol. 2003 Jun;3(6):493-502. doi: 10.1038/nri1105.