PMID- 12832285
OWN - NLM
STAT- MEDLINE
DCOM- 20030717
LR  - 20240109
IS  - 1530-6860 (Electronic)
IS  - 0892-6638 (Linking)
VI  - 17
IP  - 10
DP  - 2003 Jul
TI  - Oxidative DNA damage: mechanisms, mutation, and disease.
PG  - 1195-214
AB  - Oxidative DNA damage is an inevitable consequence of cellular metabolism, with a 
      propensity for increased levels following toxic insult. Although more than 20 
      base lesions have been identified, only a fraction of these have received 
      appreciable study, most notably 8-oxo-2'deoxyguanosine. This lesion has been the 
      focus of intense research interest and been ascribed much importance, largely to 
      the detriment of other lesions. The present work reviews the basis for the 
      biological significance of oxidative DNA damage, drawing attention to the 
      multiplicity of proteins with repair activities along with a number of poorly 
      considered effects of damage. Given the plethora of (often contradictory) reports 
      describing pathological conditions in which levels of oxidative DNA damage have 
      been measured, this review critically addresses the extent to which the in vitro 
      significance of such damage has relevance for the pathogenesis of disease. It is 
      suggested that some shortcomings associated with biomarkers, along with gaps in 
      our knowledge, may be responsible for the failure to produce consistent and 
      definitive results when applied to understanding the role of DNA damage in 
      disease, highlighting the need for further studies.
FAU - Cooke, Marcus S
AU  - Cooke MS
AD  - Oxidative Stress Group, Department of Clinical Biochemistry, University of 
      Leicester, Leicester Royal Infirmary, University Hospitals of Leicester NHS 
      Trust, Leicester, LE2 7LX, UK. msc5@le.ac.uk
FAU - Evans, Mark D
AU  - Evans MD
FAU - Dizdaroglu, Miral
AU  - Dizdaroglu M
FAU - Lunec, Joseph
AU  - Lunec J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - FASEB J
JT  - FASEB journal : official publication of the Federation of American Societies for 
      Experimental Biology
JID - 8804484
RN  - 0 (DNA Adducts)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - DNA Adducts/chemistry/metabolism
MH  - *DNA Damage
MH  - DNA Repair
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - *Mutation
MH  - Neoplasms/genetics
MH  - *Oxidative Stress
MH  - Reactive Oxygen Species/metabolism
RF  - 175
EDAT- 2003/07/02 05:00
MHDA- 2003/07/18 05:00
CRDT- 2003/07/02 05:00
PHST- 2003/07/02 05:00 [pubmed]
PHST- 2003/07/18 05:00 [medline]
PHST- 2003/07/02 05:00 [entrez]
AID - 17/10/1195 [pii]
AID - 10.1096/fj.02-0752rev [doi]
PST - ppublish
SO  - FASEB J. 2003 Jul;17(10):1195-214. doi: 10.1096/fj.02-0752rev.