PMID- 12835669
OWN - NLM
STAT- MEDLINE
DCOM- 20030826
LR  - 20220225
IS  - 1474-175X (Print)
IS  - 1474-175X (Linking)
VI  - 3
IP  - 7
DP  - 2003 Jul
TI  - Molecular mechanisms of glioma invasiveness: the role of proteases.
PG  - 489-501
AB  - The invasive nature of brain-tumour cells makes an important contribution to the 
      ineffectiveness of current treatment modalities, as the remaining tumour cells 
      inevitably infiltrate the surrounding normal brain tissue, which leads to tumour 
      recurrence. Such local invasion remains an important cause of mortality and 
      underscores the need to understand in more detail the mechanisms of tumour 
      invasiveness. Several proteases influence the malignant characteristics of 
      gliomas--could their inhibition prove to be a useful therapeutic strategy?
FAU - Rao, Jasti S
AU  - Rao JS
AD  - Program of Cancer Biology, Department of Neurosurgery, University of Illinois 
      College of Medicine-Peoria, 1 Illini Drive, Peoria, Illinois 61656, USA. 
      jsrao@uic.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Nat Rev Cancer
JT  - Nature reviews. Cancer
JID - 101124168
RN  - 0 (PLAUR protein, human)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Urokinase Plasminogen Activator)
RN  - EC 3.4.- (Endopeptidases)
RN  - EC 3.4.21.- (Plasminogen Activators)
RN  - EC 3.4.21.73 (Urokinase-Type Plasminogen Activator)
RN  - EC 3.4.22.1 (Cathepsin B)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
CIN - Nat Rev Cancer. 2003 Jul;3(7):doi:10.1038/nrc1121-c1. PMID: 19006840
MH  - Cathepsin B/metabolism
MH  - Central Nervous System Neoplasms/*metabolism/*pathology/physiopathology
MH  - Endopeptidases/*physiology
MH  - Glioma/*metabolism/*pathology/physiopathology
MH  - Humans
MH  - Matrix Metalloproteinases/metabolism
MH  - Neoplasm Invasiveness
MH  - Neoplasm Recurrence, Local/metabolism
MH  - Plasminogen Activators/metabolism
MH  - Receptors, Cell Surface/metabolism
MH  - Receptors, Urokinase Plasminogen Activator
MH  - Urokinase-Type Plasminogen Activator/metabolism
RF  - 146
EDAT- 2003/07/02 05:00
MHDA- 2003/08/27 05:00
CRDT- 2003/07/02 05:00
PHST- 2003/07/02 05:00 [pubmed]
PHST- 2003/08/27 05:00 [medline]
PHST- 2003/07/02 05:00 [entrez]
AID - nrc1121 [pii]
AID - 10.1038/nrc1121 [doi]
PST - ppublish
SO  - Nat Rev Cancer. 2003 Jul;3(7):489-501. doi: 10.1038/nrc1121.