PMID- 12876559
OWN - NLM
STAT- MEDLINE
DCOM- 20031117
LR  - 20220330
IS  - 1474-1733 (Print)
IS  - 1474-1733 (Linking)
VI  - 3
IP  - 7
DP  - 2003 Jul
TI  - Three or more routes for leukocyte migration into the central nervous system.
PG  - 569-81
AB  - Leukocyte migration into and through tissues is fundamental to normal physiology, 
      immunopathology and host defence. Leukocyte entry into the central nervous system 
      (CNS) is restricted, in part, because of the blood-brain barrier (BBB). During 
      the past decade, crucial components that are involved in the process of leukocyte 
      migration have been identified and progress has been made in understanding the 
      mechanisms of neuroinflammatory reactions. In this review, present knowledge of 
      the trafficking determinants that guide the migration of leukocytes is 
      superimposed onto the vascular and compartmental anatomy of the CNS. We discuss 
      three distinct routes for leukocytes to enter the CNS and consider how different 
      populations of leukocytes use trafficking signals to gain entry.
FAU - Ransohoff, Richard M
AU  - Ransohoff RM
AD  - The Mellen Center for Multiple Sclerosis Treatment and Research, Department of 
      Neurology, 9500 Euclid Avenue, The Cleveland Clinic Foundation, Cleveland, Ohio 
      44195, USA. ransohr@ccf.org
FAU - Kivisakk, Pia
AU  - Kivisakk P
FAU - Kidd, Grahame
AU  - Kidd G
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Nat Rev Immunol
JT  - Nature reviews. Immunology
JID - 101124169
RN  - 0 (Receptors, Antigen, T-Cell, gamma-delta)
SB  - IM
MH  - Animals
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Cell Movement
MH  - Central Nervous System/blood supply/*immunology/pathology
MH  - Cerebrospinal Fluid/immunology
MH  - Encephalomyelitis, Autoimmune, Experimental/immunology/pathology
MH  - Humans
MH  - Immunologic Surveillance
MH  - Killer Cells, Natural/immunology
MH  - Lymphocytes/*immunology
MH  - Neutrophils/immunology
MH  - Phagocytes/immunology
MH  - Receptors, Antigen, T-Cell, gamma-delta/immunology
MH  - Spinal Cord/immunology
RF  - 121
EDAT- 2003/07/24 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/07/24 05:00
PHST- 2003/07/24 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/07/24 05:00 [entrez]
AID - nri1130 [pii]
AID - 10.1038/nri1130 [doi]
PST - ppublish
SO  - Nat Rev Immunol. 2003 Jul;3(7):569-81. doi: 10.1038/nri1130.