PMID- 12954073
OWN - NLM
STAT- MEDLINE
DCOM- 20031110
LR  - 20221207
IS  - 0022-2623 (Print)
IS  - 0022-2623 (Linking)
VI  - 46
IP  - 19
DP  - 2003 Sep 11
TI  - Synthesis and cytotoxic activity of two novel 
      1-dodecylthio-2-decyloxypropyl-3-phosphatidic acid conjugates with gemcitabine 
      and cytosine arabinoside.
PG  - 4205-8
AB  - Cytosine arabinoside (ara-C) and gemcitabine (dFdC) are two standard chemotherapy 
      drugs used in the treatment of patients with various cancers. To alter the 
      pharmacokinetic and pharmacodynamic properties of these molecules, we conjugated 
      a synthetic phospholipid to both ara-C and dFdC and investigated their 
      chemotherapeutic potential. The dFdC conjugate had greater cytotoxic activity 
      compared with the ara-C conjugate and demonstrated notable cytotoxicity against 
      all human cell lines tested.
FAU - Alexander, Richard L
AU  - Alexander RL
AD  - Department of Physiology and Pharmacology, Wake Forest University School of 
      Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27517, USA.
FAU - Morris-Natschke, Susan L
AU  - Morris-Natschke SL
FAU - Ishaq, Khalid S
AU  - Ishaq KS
FAU - Fleming, Ronald A
AU  - Fleming RA
FAU - Kucera, Gregory L
AU  - Kucera GL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Med Chem
JT  - Journal of medicinal chemistry
JID - 9716531
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Buffers)
RN  - 0 (Phosphatidic Acids)
RN  - 04079A1RDZ (Cytarabine)
RN  - 0W860991D6 (Deoxycytidine)
RN  - EC 1.17.4.- (Ribonucleotide Reductases)
RN  - 0 (Gemcitabine)
SB  - IM
MH  - Antineoplastic Agents/chemical 
      synthesis/*chemistry/pharmacokinetics/*pharmacology
MH  - Buffers
MH  - Cell Line
MH  - Cytarabine/*analogs & derivatives/pharmacology
MH  - Deoxycytidine/*analogs & derivatives/*chemistry/pharmacology
MH  - Humans
MH  - Inhibitory Concentration 50
MH  - Phosphatidic Acids/chemical synthesis/*chemistry/pharmacokinetics/*pharmacology
MH  - Ribonucleotide Reductases/antagonists & inhibitors
MH  - Solubility
MH  - Gemcitabine
EDAT- 2003/09/05 05:00
MHDA- 2003/11/11 05:00
CRDT- 2003/09/05 05:00
PHST- 2003/09/05 05:00 [pubmed]
PHST- 2003/11/11 05:00 [medline]
PHST- 2003/09/05 05:00 [entrez]
AID - 10.1021/jm020571x [doi]
PST - ppublish
SO  - J Med Chem. 2003 Sep 11;46(19):4205-8. doi: 10.1021/jm020571x.