PMID- 1334098
OWN - NLM
STAT- MEDLINE
DCOM- 19930112
LR  - 20190824
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 41
IP  - 1
DP  - 1992 Nov
TI  - Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and 
      other inflammatory neurological disorders.
PG  - 29-34
AB  - A substrate conversion assay was used to detect gelatinase activity in the 
      cerebrospinal fluid (CSF) of patients with various neurological disorders. Two 
      main forms of gelatinase with an apparent molecular mass of 65 and 85 kDa, 
      respectively, could be discerned. The high molecular mass gelatinase was 
      detectable only in samples of patients with multiple sclerosis or other 
      inflammatory neurological disorders. A statistically significant correlation was 
      found between the level of the 85-kDa gelatinase and the CSF cytosis. This 
      protease could play a role in the process of demyelination and breakdown of the 
      blood-brain barrier in certain neurological disorders, such as multiple 
      sclerosis.
FAU - Gijbels, K
AU  - Gijbels K
AD  - Rega Institute, Leuven, Belgium.
FAU - Masure, S
AU  - Masure S
FAU - Carton, H
AU  - Carton H
FAU - Opdenakker, G
AU  - Opdenakker G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Protease Inhibitors)
RN  - EC 3.4.23.1 (Pepsin A)
RN  - EC 3.4.24.- (Gelatinases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Central Nervous System Diseases/*enzymology
MH  - Electrophoresis, Polyacrylamide Gel
MH  - Female
MH  - Gelatinases
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Molecular Weight
MH  - Multiple Sclerosis/*enzymology
MH  - Pepsin A/*cerebrospinal fluid/chemistry/drug effects
MH  - Protease Inhibitors/pharmacology
EDAT- 1992/11/01 00:00
MHDA- 2000/06/01 00:00
CRDT- 1992/11/01 00:00
PHST- 1992/11/01 00:00 [pubmed]
PHST- 2000/06/01 00:00 [medline]
PHST- 1992/11/01 00:00 [entrez]
AID - 0165-5728(92)90192-N [pii]
AID - 10.1016/0165-5728(92)90192-n [doi]
PST - ppublish
SO  - J Neuroimmunol. 1992 Nov;41(1):29-34. doi: 10.1016/0165-5728(92)90192-n.