PMID- 1339340 OWN - NLM STAT- MEDLINE DCOM- 19930420 LR - 20220215 IS - 0950-1991 (Print) IS - 0950-1991 (Linking) VI - 116 IP - 4 DP - 1992 Dec TI - ming is expressed in neuroblast sublineages and regulates gene expression in the Drosophila central nervous system. PG - 943-52 AB - Cell diversity in the Drosophila central nervous system (CNS) is primarily generated by the invariant lineage of neural precursors called neuroblasts. We used an enhancer trap screen to identify the ming gene, which is transiently expressed in a subset of neuroblasts at reproducible points in their cell lineage (i.e. in neuroblast 'sublineages'), suggesting that neuroblast identity can be altered during its cell lineage. ming encodes a predicted zinc finger protein and loss of ming function results in precise alterations in CNS gene expression, defects in axonogenesis and embryonic lethality. We propose that ming controls cell fate within neuroblast cell lineages. FAU - Cui, X AU - Cui X AD - Department of Cell and Structural Biology, University of Illinois, Urbana 61801. FAU - Doe, C Q AU - Doe CQ LA - eng SI - GENBANK/L12697 SI - GENBANK/L12698 SI - GENBANK/L12699 SI - GENBANK/L12700 SI - GENBANK/L12701 SI - GENBANK/L12702 SI - GENBANK/L12703 SI - GENBANK/X69698 SI - GENBANK/Z15091 SI - GENBANK/Z16406 GR - R01-27056/PHS HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Research Support, U.S. Gov't, P.H.S. PL - England TA - Development JT - Development (Cambridge, England) JID - 8701744 SB - IM GS - ming MH - Amino Acid Sequence MH - Animals MH - Base Sequence MH - Cell Differentiation/genetics MH - Central Nervous System/*embryology MH - Drosophila/*embryology/genetics MH - Enhancer Elements, Genetic MH - Gene Expression Regulation/*genetics MH - Genes, Regulator/*physiology MH - Molecular Sequence Data MH - Neurons/*physiology EDAT- 1992/12/01 00:00 MHDA- 1992/12/01 00:01 CRDT- 1992/12/01 00:00 PHST- 1992/12/01 00:00 [pubmed] PHST- 1992/12/01 00:01 [medline] PHST- 1992/12/01 00:00 [entrez] AID - 10.1242/dev.116.4.943 [doi] PST - ppublish SO - Development. 1992 Dec;116(4):943-52. doi: 10.1242/dev.116.4.943.