PMID- 1350328
OWN - NLM
STAT- MEDLINE
DCOM- 19920625
LR  - 20220318
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 357
IP  - 6376
DP  - 1992 May 28
TI  - Changing role of even-skipped during the evolution of insect pattern formation.
PG  - 339-42
AB  - The development of Drosophila is typical of the so-called long germband mode of 
      insect development, in which the pattern of segments is established by the end of 
      the blastoderm stage. Short germband insects, such as the grasshopper 
      Schistocerca americana, by contrast, generate all or most of their metameric 
      pattern after the blastoderm stage by the sequential addition of segments during 
      caudal elongation. This difference is discernible at the molecular level in the 
      pattern of initiation of the segment polarity gene engrailed, and the homeotic 
      gene abdominal-A (ref. 5). For example, in both types of insects, engrailed is 
      expressed by the highly conserved germband stage in a pattern of regularly spaced 
      stripes, one stripe per segment. In Drosophila, the complete pattern is visible 
      by the end of the blastoderm stage, although engrailed appears initially in 
      alternate segments in a pair-rule pattern that reflects its known control by 
      pair-rule genes such as even-skipped. In contrast, in the grasshopper, the 
      engrailed stripes appear one at a time after the blastoderm stage as the embryo 
      elongates. To address the molecular basis for this difference, we have cloned the 
      grasshopper homologue of the Drosophila pair-rule gene even-skipped and show that 
      it does not serve a pair-rule function in early development, although it does 
      have a similar function in both insects during neurogenesis later in development.
FAU - Patel, N H
AU  - Patel NH
AD  - Howard Hughes Medical Institute, Department of Molecular and Cell Biology, 
      University of California, Berkeley 94720.
FAU - Ball, E E
AU  - Ball EE
FAU - Goodman, C S
AU  - Goodman CS
LA  - eng
SI  - GENBANK/Z11845
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blastoderm/metabolism
MH  - Blotting, Southern
MH  - Cloning, Molecular
MH  - DNA/genetics
MH  - Drosophila/*embryology/*genetics
MH  - Gene Expression Regulation
MH  - Genes, Homeobox/genetics
MH  - Grasshoppers/*embryology/*genetics
MH  - Molecular Sequence Data
MH  - Nervous System/embryology
MH  - Neurons/metabolism
MH  - Rats
MH  - Sequence Homology, Nucleic Acid
EDAT- 1992/05/28 00:00
MHDA- 1992/05/28 00:01
CRDT- 1992/05/28 00:00
PHST- 1992/05/28 00:00 [pubmed]
PHST- 1992/05/28 00:01 [medline]
PHST- 1992/05/28 00:00 [entrez]
AID - 10.1038/357339a0 [doi]
PST - ppublish
SO  - Nature. 1992 May 28;357(6376):339-42. doi: 10.1038/357339a0.