PMID- 1372131
OWN - NLM
STAT- MEDLINE
DCOM- 19920415
LR  - 20190618
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 255
IP  - 5048
DP  - 1992 Feb 28
TI  - Cytokine stimulation of multilineage hematopoiesis from immature human cells 
      engrafted in SCID mice.
PG  - 1137-41
AB  - Severe combined immunodeficient (SCID) mice transplanted with human bone marrow 
      were treated with human mast cell growth factor, a fusion of interleukin-3 and 
      granulocyte-macrophage colony-stimulating factor (PIXY321), or both, starting 
      immediately or 1 month later. Immature human cells repopulated the mouse bone 
      marrow with differentiated human cells of multiple myeloid and lymphoid lineages; 
      inclusion of erythropoietin resulted in human red cells in the peripheral blood. 
      The bone marrow of growth factor-treated mice contained both multipotential and 
      committed myeloid and erythroid progenitors, whereas mice not given growth 
      factors had few human cells and only granulocyte-macrophage progenitors. Thus, 
      this system allows the detection of immature human cells, identification of the 
      growth factors that regulate them, and the establishment of animal models of 
      human hematopoietic diseases.
FAU - Lapidot, T
AU  - Lapidot T
AD  - Department of Genetics, Research Institute, Hospital for Sick Children, Toronto, 
      Ontario, Canada.
FAU - Pflumio, F
AU  - Pflumio F
FAU - Doedens, M
AU  - Doedens M
FAU - Murdoch, B
AU  - Murdoch B
FAU - Williams, D E
AU  - Williams DE
FAU - Dick, J E
AU  - Dick JE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Cytokines)
RN  - 0 (Hematopoietic Cell Growth Factors)
RN  - 0 (Interleukin-3)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Stem Cell Factor)
RN  - 11096-26-7 (Erythropoietin)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Animals
MH  - Bone Marrow Cells
MH  - *Bone Marrow Transplantation
MH  - Cytokines/*pharmacology
MH  - Erythropoietin/pharmacology
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology
MH  - *Hematopoiesis
MH  - Hematopoietic Cell Growth Factors/pharmacology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Interleukin-3/pharmacology
MH  - Mice
MH  - Mice, SCID
MH  - Recombinant Fusion Proteins/pharmacology
MH  - Stem Cell Factor
EDAT- 1992/02/28 00:00
MHDA- 1992/02/28 00:01
CRDT- 1992/02/28 00:00
PHST- 1992/02/28 00:00 [pubmed]
PHST- 1992/02/28 00:01 [medline]
PHST- 1992/02/28 00:00 [entrez]
AID - 10.1126/science.1372131 [doi]
PST - ppublish
SO  - Science. 1992 Feb 28;255(5048):1137-41. doi: 10.1126/science.1372131.