PMID- 1436033
OWN - NLM
STAT- MEDLINE
DCOM- 19921127
LR  - 20220317
IS  - 0028-0836 (Print)
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 359
IP  - 6397
DP  - 1992 Oct 22
TI  - Targeted disruption of the mouse transforming growth factor-beta 1 gene results 
      in multifocal inflammatory disease.
PG  - 693-9
AB  - Transforming growth factor-beta 1 (TGF-beta 1) is a multifunctional growth factor 
      that has profound regulatory effects on many developmental and physiological 
      processes. Disruption of the TGF-beta 1 gene by homologous recombination in 
      murine embryonic stem cells enables mice to be generated that carry the disrupted 
      allele. Animals homozygous for the mutated TGF-beta 1 allele show no gross 
      developmental abnormalities, but about 20 days after birth they succumb to a 
      wasting syndrome accompanied by a multifocal, mixed inflammatory cell response 
      and tissue necrosis, leading to organ failure and death. TGF-beta 1-deficient 
      mice may be valuable models for human immune and inflammatory disorders, 
      including autoimmune diseases, transplant rejection and graft versus host 
      reactions.
FAU - Shull, M M
AU  - Shull MM
AD  - Department of Molecular Genetics, Biochemistry, and Microbiology, University of 
      Cincinnati College of Medicine, Ohio 45267-0524.
FAU - Ormsby, I
AU  - Ormsby I
FAU - Kier, A B
AU  - Kier AB
FAU - Pawlowski, S
AU  - Pawlowski S
FAU - Diebold, R J
AU  - Diebold RJ
FAU - Yin, M
AU  - Yin M
FAU - Allen, R
AU  - Allen R
FAU - Sidman, C
AU  - Sidman C
FAU - Proetzel, G
AU  - Proetzel G
FAU - Calvin, D
AU  - Calvin D
AU  - et al.
LA  - eng
GR  - R01 HD026471/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Cytokines)
RN  - 0 (Oligodeoxyribonucleotides)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Cytokines/genetics
MH  - Gene Expression
MH  - Genes
MH  - Homozygote
MH  - Inflammation/*genetics/pathology
MH  - Leukocyte Count
MH  - Mice
MH  - Mice, Transgenic
MH  - Molecular Sequence Data
MH  - Mutagenesis, Insertional
MH  - Necrosis
MH  - Oligodeoxyribonucleotides/chemistry
MH  - Polymerase Chain Reaction
MH  - RNA, Messenger/genetics
MH  - Restriction Mapping
MH  - Transforming Growth Factor beta/*physiology
PMC - PMC3889166
MID - NIHMS544637
EDAT- 1992/10/22 00:00
MHDA- 1992/10/22 00:01
PMCR- 2014/01/13
CRDT- 1992/10/22 00:00
PHST- 1992/10/22 00:00 [pubmed]
PHST- 1992/10/22 00:01 [medline]
PHST- 1992/10/22 00:00 [entrez]
PHST- 2014/01/13 00:00 [pmc-release]
AID - 10.1038/359693a0 [doi]
PST - ppublish
SO  - Nature. 1992 Oct 22;359(6397):693-9. doi: 10.1038/359693a0.