PMID- 14657486 OWN - NLM STAT- MEDLINE DCOM- 20031229 LR - 20221109 IS - 1095-9203 (Electronic) IS - 0036-8075 (Linking) VI - 302 IP - 5651 DP - 2003 Dec 5 TI - Cell migration: integrating signals from front to back. PG - 1704-9 AB - Cell migration is a highly integrated multistep process that orchestrates embryonic morphogenesis; contributes to tissue repair and regeneration; and drives disease progression in cancer, mental retardation, atherosclerosis, and arthritis. The migrating cell is highly polarized with complex regulatory pathways that spatially and temporally integrate its component processes. This review describes the mechanisms underlying the major steps of migration and the signaling pathways that regulate them, and outlines recent advances investigating the nature of polarity in migrating cells and the pathways that establish it. FAU - Ridley, Anne J AU - Ridley AJ AD - Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London W1W 7BS, UK. FAU - Schwartz, Martin A AU - Schwartz MA FAU - Burridge, Keith AU - Burridge K FAU - Firtel, Richard A AU - Firtel RA FAU - Ginsberg, Mark H AU - Ginsberg MH FAU - Borisy, Gary AU - Borisy G FAU - Parsons, J Thomas AU - Parsons JT FAU - Horwitz, Alan Rick AU - Horwitz AR LA - eng PT - Journal Article PT - Review PL - United States TA - Science JT - Science (New York, N.Y.) JID - 0404511 RN - 0 (Integrins) RN - 0 (Proteins) SB - IM MH - Actin Cytoskeleton/physiology MH - Animals MH - Cell Adhesion MH - *Cell Movement MH - Cell Polarity MH - Humans MH - Integrins/physiology MH - Models, Biological MH - Proteins/metabolism MH - Pseudopodia/physiology MH - *Signal Transduction RF - 58 EDAT- 2003/12/06 05:00 MHDA- 2003/12/31 05:00 CRDT- 2003/12/06 05:00 PHST- 2003/12/06 05:00 [pubmed] PHST- 2003/12/31 05:00 [medline] PHST- 2003/12/06 05:00 [entrez] AID - 302/5651/1704 [pii] AID - 10.1126/science.1092053 [doi] PST - ppublish SO - Science. 2003 Dec 5;302(5651):1704-9. doi: 10.1126/science.1092053.