PMID- 14697673 OWN - NLM STAT- MEDLINE DCOM- 20040227 LR - 20191108 IS - 1044-7431 (Print) IS - 1044-7431 (Linking) VI - 24 IP - 4 DP - 2003 Dec TI - Constitutive EGFR signaling confers a motile phenotype to neural stem cells. PG - 1116-30 AB - The epidermal growth factor receptor (EGFR) has been shown to play an important role in brain development, including stem and precursor cell survival, proliferation, differentiation, and migration. To further examine the temporal and spatial requirements of erbB signals in uncommitted neural stem cells (NSCs), we expressed the ligand-independent EGF receptor, EGFRvIII, in C17.2 NSCs. These NSCs are known to migrate and to evince a tropic response to neurodegenerative environments in vivo but for which an underlying mechanism remains unclear. We show that enhanced erbB signaling via constitutive kinase activity of EGFRvIII in NSCs sustains an immature phenotype and enhances NSC migration. FAU - Boockvar, John A AU - Boockvar JA AD - Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. boockvaj@uphs.upenn.edu FAU - Kapitonov, Dmitri AU - Kapitonov D FAU - Kapoor, Gurpreet AU - Kapoor G FAU - Schouten, Joost AU - Schouten J FAU - Counelis, George J AU - Counelis GJ FAU - Bogler, Oliver AU - Bogler O FAU - Snyder, Evan Y AU - Snyder EY FAU - McIntosh, Tracy K AU - McIntosh TK FAU - O'Rourke, Donald M AU - O'Rourke DM LA - eng GR - F32 044750/PHS HHS/United States GR - GM 34690/GM/NIGMS NIH HHS/United States GR - N508803/PHS HHS/United States GR - NS 40978/NS/NINDS NIH HHS/United States GR - R01 CA90586/CA/NCI NIH HHS/United States PT - Journal Article PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Mol Cell Neurosci JT - Molecular and cellular neurosciences JID - 9100095 RN - 0 (epidermal growth factor receptor VIII) RN - EC 2.7.10.1 (ErbB Receptors) SB - IM MH - Animals MH - Cell Movement/*physiology MH - ErbB Receptors/*biosynthesis/*genetics MH - Genes, erbB-1/physiology MH - Male MH - Neurons/*metabolism MH - *Phenotype MH - Rats MH - Rats, Sprague-Dawley MH - Signal Transduction/physiology MH - Stem Cells/*metabolism EDAT- 2003/12/31 05:00 MHDA- 2004/02/28 05:00 CRDT- 2003/12/31 05:00 PHST- 2003/12/31 05:00 [pubmed] PHST- 2004/02/28 05:00 [medline] PHST- 2003/12/31 05:00 [entrez] AID - S1044743103002872 [pii] AID - 10.1016/j.mcn.2003.09.011 [doi] PST - ppublish SO - Mol Cell Neurosci. 2003 Dec;24(4):1116-30. doi: 10.1016/j.mcn.2003.09.011.