PMID- 15001240
OWN - NLM
STAT- MEDLINE
DCOM- 20040401
LR  - 20220316
IS  - 0360-3016 (Print)
IS  - 0360-3016 (Linking)
VI  - 58
IP  - 4
DP  - 2004 Mar 15
TI  - Phase I study of stereotactic radiosurgery in patients with locally advanced 
      pancreatic cancer.
PG  - 1017-21
AB  - PURPOSE: To determine the feasibility and toxicity of delivering stereotactic 
      radiosurgery to patients with locally advanced pancreatic cancer. METHODS AND 
      MATERIALS: Patients with Eastern Cooperative Oncology Group performance status < 
      or=2 and locally advanced pancreatic cancer were enrolled on this Phase I dose 
      escalation study. Patients received a single fraction of radiosurgery consisting 
      of either 15 Gy, 20 Gy, or 25 Gy to the primary tumor. Acute gastrointestinal 
      toxicity was scored according to the Radiation Therapy Oncology Group criteria. 
      Response to treatment was determined by serial high-resolution computed 
      tomography scanning. RESULTS: Fifteen patients were treated at 3 dose levels (3 
      patients received 15 Gy, 5 patients received 20 Gy, and 7 patients received 25 
      Gy). At these doses, no Grade 3 or higher acute gastrointestinal toxicity was 
      observed. This trial was stopped before any dose-limiting toxicity was reached, 
      because the clinical objective of local control was achieved in all 6 evaluable 
      patients treated at 25 Gy. CONCLUSIONS: It is feasible to deliver stereotactic 
      radiosurgery to patients with locally advanced pancreatic cancer. The recommended 
      dose to achieve local control without significant acute gastrointestinal toxicity 
      is 25 Gy.
FAU - Koong, Albert C
AU  - Koong AC
AD  - Department of Radiation Oncology, Stanford University, Stanford, California 
      94305-5152, USA. akoong@stanford.edu
FAU - Le, Quynh T
AU  - Le QT
FAU - Ho, Anthony
AU  - Ho A
FAU - Fong, Bryan
AU  - Fong B
FAU - Fisher, George
AU  - Fisher G
FAU - Cho, Cheryl
AU  - Cho C
FAU - Ford, Jim
AU  - Ford J
FAU - Poen, Joseph
AU  - Poen J
FAU - Gibbs, Iris C
AU  - Gibbs IC
FAU - Mehta, Vivek K
AU  - Mehta VK
FAU - Kee, Stephen
AU  - Kee S
FAU - Trueblood, Ward
AU  - Trueblood W
FAU - Yang, George
AU  - Yang G
FAU - Bastidas, J Augusto
AU  - Bastidas JA
LA  - eng
PT  - Clinical Trial
PT  - Clinical Trial, Phase I
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Feasibility Studies
MH  - Humans
MH  - Middle Aged
MH  - Pancreatic Neoplasms/pathology/*surgery
MH  - *Radiosurgery
MH  - Radiotherapy Dosage
EDAT- 2004/03/06 05:00
MHDA- 2004/04/02 05:00
CRDT- 2004/03/06 05:00
PHST- 2003/09/15 00:00 [received]
PHST- 2003/10/31 00:00 [revised]
PHST- 2003/11/03 00:00 [accepted]
PHST- 2004/03/06 05:00 [pubmed]
PHST- 2004/04/02 05:00 [medline]
PHST- 2004/03/06 05:00 [entrez]
AID - S0360301603022946 [pii]
AID - 10.1016/j.ijrobp.2003.11.004 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2004 Mar 15;58(4):1017-21. doi: 
      10.1016/j.ijrobp.2003.11.004.