PMID- 15165905
OWN - NLM
STAT- MEDLINE
DCOM- 20040630
LR  - 20121115
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 567
IP  - 1
DP  - 2004 Jun 1
TI  - Matrix metalloproteinases and their endogenous inhibitors in neuronal physiology 
      of the adult brain.
PG  - 129-35
AB  - More than 20 matrix metalloproteinases (MMPs) and four of their endogenous tissue 
      inhibitors (TIMPs) act together to control tightly temporally restricted, focal 
      proteolysis of extracellular matrix. In the neurons of the adult brain several 
      components of the TIMP/MMP system are expressed and are responsive to changes in 
      neuronal activity. Furthermore, functional studies, especially involving blocking 
      of MMP activities, along with the identification of MMP substrates in the brain 
      strongly suggest that this enzymatic system plays an important physiological role 
      in adult brain neurons, possibly being pivotal for neuronal plasticity.
FAU - Dzwonek, Joanna
AU  - Dzwonek J
AD  - Department of Molecular and Cellular Neurobiology, Nencki Institute, 02-093 
      Warsaw, Pasteura 3, Poland.
FAU - Rylski, Marcin
AU  - Rylski M
FAU - Kaczmarek, Leszek
AU  - Kaczmarek L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Matrix Metalloproteinase Inhibitors)
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Adult
MH  - Brain/*enzymology/metabolism
MH  - Humans
MH  - Matrix Metalloproteinase 9/metabolism
MH  - *Matrix Metalloproteinase Inhibitors
MH  - Matrix Metalloproteinases/*physiology
MH  - Memory
MH  - Models, Biological
MH  - Neurons/*enzymology/metabolism
MH  - Tissue Inhibitor of Metalloproteinases/*metabolism/*physiology
RF  - 78
EDAT- 2004/05/29 05:00
MHDA- 2004/07/01 05:00
CRDT- 2004/05/29 05:00
PHST- 2004/02/19 00:00 [received]
PHST- 2004/03/03 00:00 [revised]
PHST- 2004/03/07 00:00 [accepted]
PHST- 2004/05/29 05:00 [pubmed]
PHST- 2004/07/01 05:00 [medline]
PHST- 2004/05/29 05:00 [entrez]
AID - S0014579304003746 [pii]
AID - 10.1016/j.febslet.2004.03.070 [doi]
PST - ppublish
SO  - FEBS Lett. 2004 Jun 1;567(1):129-35. doi: 10.1016/j.febslet.2004.03.070.