PMID- 1522901
OWN - NLM
STAT- MEDLINE
DCOM- 19921013
LR  - 20190523
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 359
IP  - 6391
DP  - 1992 Sep 10
TI  - Loss of gene function through rapid mitotic cycles in the Drosophila embryo.
PG  - 156-9
AB  - The early developmental period in Drosophila is characterized by rapid mitotic 
      divisions, when the body pattern becomes organized by a cascade of segmentation 
      gene activity. During this process localized expression of the gap gene knirps 
      (kni) is required to establish abdomen segmentation. The knirps-related gene 
      (knrl) encodes a kni-homologous nuclear hormone receptor-like protein and shares 
      the spatial patterns of kni expression. The two genes differ with respect to the 
      size of their transcription units; kni contains 1 kilobase and knrl 19 kilobases 
      of intron sequences. The consequence of this difference in intron size is that 
      knrl cannot substitute for kni segmentation function, although it gains this 
      ability when expressed from an intronless transgene. Here we show that the length 
      of mitotic cycles provides a physiological barrier to transcript size, and is 
      therefore a significant factor in controlling developmental gene activity during 
      short 'phenocritical' periods. The required coordination of cycle length and gene 
      size provides severe constraints towards the evolution of rapid development.
FAU - Rothe, M
AU  - Rothe M
AD  - Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare 
      Entwicklungsbiologie, Gottingen, Germany.
FAU - Pehl, M
AU  - Pehl M
FAU - Taubert, H
AU  - Taubert H
FAU - Jackle, H
AU  - Jackle H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Insect Hormones)
RN  - 0 (Repressor Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (bcd protein, Drosophila)
RN  - 0 (kni protein, Drosophila)
SB  - IM
GS  - kni
GS  - knrl
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cell Cycle/physiology
MH  - DNA-Binding Proteins/physiology
MH  - Drosophila/*embryology/*genetics
MH  - *Drosophila Proteins
MH  - *Gene Expression Regulation
MH  - Genes/*physiology
MH  - *Genes, Developmental
MH  - *Homeodomain Proteins
MH  - Insect Hormones/physiology
MH  - Mitosis/*physiology
MH  - Molecular Sequence Data
MH  - Nucleic Acid Hybridization
MH  - Repressor Proteins/physiology
MH  - Trans-Activators/physiology
MH  - Transcription, Genetic
MH  - Transfection
EDAT- 1992/09/10 00:00
MHDA- 1992/09/10 00:01
CRDT- 1992/09/10 00:00
PHST- 1992/09/10 00:00 [pubmed]
PHST- 1992/09/10 00:01 [medline]
PHST- 1992/09/10 00:00 [entrez]
AID - 10.1038/359156a0 [doi]
PST - ppublish
SO  - Nature. 1992 Sep 10;359(6391):156-9. doi: 10.1038/359156a0.