PMID- 15253384
OWN - NLM
STAT- MEDLINE
DCOM- 20050106
LR  - 20191108
IS  - 0897-7194 (Print)
IS  - 0897-7194 (Linking)
VI  - 22
IP  - 2
DP  - 2004 Jun
TI  - Signalling by the type 1 insulin-like growth factor receptor: interplay with the 
      epidermal growth factor receptor.
PG  - 89-95
AB  - The type 1 insulin-like growth factor receptor (IGF-1R) plays an essential role 
      in mammalian growth and development, and has emerged as a candidate therapeutic 
      target in the treatment of cancer. While the pleiotropic cellular responses 
      elicited following tyrosine phosphorylation of the IGF-1R is usually seen to 
      involve the direct recruitment/activation of classical intracellular effector 
      proteins, it is now clear that cross-talk between the IGF-1R and members of 
      distinct receptor families also plays a significant role in effecting 
      intracellular signalling. In recent years, a number of studies have highlighted 
      the interaction(s) between the IGF-1R and the epidermal growth factor receptor 
      (EGFR), another transmembrane tyrosine kinase that is an established cancer 
      target. This review describes the components of the IGF signalling system and 
      gives an overview of the emerging picture of the interrelationship that is now 
      known to exist between the IGF and EGF receptors.
FAU - Adams, Timothy E
AU  - Adams TE
AD  - CSIRO Health Sciences and Nutrition, 343 Royal Parade, Parkville, VIC. 3052, 
      Australia. tim.adams@csiro.au
FAU - McKern, Neil M
AU  - McKern NM
FAU - Ward, Colin W
AU  - Ward CW
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Growth Factors
JT  - Growth factors (Chur, Switzerland)
JID - 9000468
RN  - 0 (Ligands)
RN  - 42HK56048U (Tyrosine)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 2.7.10.1 (Receptor, IGF Type 1)
SB  - IM
MH  - Cell Line, Tumor
MH  - Cell Proliferation
MH  - ErbB Receptors/*metabolism
MH  - Humans
MH  - Ligands
MH  - Phosphorylation
MH  - Protein Structure, Tertiary
MH  - Receptor, IGF Type 1/chemistry/*metabolism
MH  - *Signal Transduction
MH  - Tyrosine/chemistry
RF  - 60
EDAT- 2004/07/16 05:00
MHDA- 2005/01/07 09:00
CRDT- 2004/07/16 05:00
PHST- 2004/07/16 05:00 [pubmed]
PHST- 2005/01/07 09:00 [medline]
PHST- 2004/07/16 05:00 [entrez]
AID - 10.1080/08977190410001700998 [doi]
PST - ppublish
SO  - Growth Factors. 2004 Jun;22(2):89-95. doi: 10.1080/08977190410001700998.