PMID- 15340416
OWN - NLM
STAT- MEDLINE
DCOM- 20041220
LR  - 20240104
IS  - 1078-8956 (Print)
IS  - 1078-8956 (Linking)
VI  - 10
IP  - 9
DP  - 2004 Sep
TI  - Cancer immunotherapy: moving beyond current vaccines.
PG  - 909-15
AB  - Great progress has been made in the field of tumor immunology in the past decade, 
      but optimism about the clinical application of currently available cancer vaccine 
      approaches is based more on surrogate endpoints than on clinical tumor 
      regression. In our cancer vaccine trials of 440 patients, the objective response 
      rate was low (2.6%), and comparable to the results obtained by others. We 
      consider here results in cancer vaccine trials and highlight alternate strategies 
      that mediate cancer regression in preclinical and clinical models.
FAU - Rosenberg, Steven A
AU  - Rosenberg SA
AD  - Surgery Branch of the Center for Cancer Research at the National Cancer 
      Institute, Building 10, Room 2B42, 10 Center Drive, MSC 1502 Bethesda, Maryland 
      20892-1502, USA. sar@mail.nih.gov
FAU - Yang, James C
AU  - Yang JC
FAU - Restifo, Nicholas P
AU  - Restifo NP
LA  - eng
GR  - Z01 BC010763-01/Intramural NIH HHS/United States
GR  - Z99 CA999999/Intramural NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Nat Med
JT  - Nature medicine
JID - 9502015
RN  - 0 (Cancer Vaccines)
RN  - 0 (Vaccines, Subunit)
SB  - IM
CIN - Nat Med. 2004 Dec;10(12):1278-9; author reply 1279-80. PMID: 15580242
CIN - Nat Med. 2004 Dec;10(12):1279; author reply 1279-80. PMID: 15682512
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cancer Vaccines/*therapeutic use
MH  - Child
MH  - Clinical Trials as Topic
MH  - Female
MH  - Humans
MH  - Immunotherapy/*methods
MH  - Male
MH  - Middle Aged
MH  - *Models, Immunological
MH  - Neoplasm Metastasis/immunology/*therapy
MH  - Neoplasms/immunology/*therapy
MH  - T-Lymphocytes/immunology
MH  - Treatment Outcome
MH  - Vaccines, Subunit/therapeutic use
PMC - PMC1435696
MID - NIHMS9070
EDAT- 2004/09/02 05:00
MHDA- 2004/12/21 09:00
PMCR- 2008/01/26
CRDT- 2004/09/02 05:00
PHST- 2004/09/02 05:00 [pubmed]
PHST- 2004/12/21 09:00 [medline]
PHST- 2004/09/02 05:00 [entrez]
PHST- 2008/01/26 00:00 [pmc-release]
AID - nm1100 [pii]
AID - 10.1038/nm1100 [doi]
PST - ppublish
SO  - Nat Med. 2004 Sep;10(9):909-15. doi: 10.1038/nm1100.