PMID- 15360265
OWN - NLM
STAT- MEDLINE
DCOM- 20050222
LR  - 20051116
IS  - 1525-7797 (Print)
IS  - 1525-7797 (Linking)
VI  - 5
IP  - 5
DP  - 2004 Sep-Oct
TI  - Poly(ortho esters)--from concept to reality.
PG  - 1625-32
AB  - The development of poly(ortho esters) dates back to the early 1970s, and during 
      that time, four distinct families were developed. These polymers can be prepared 
      by a transesterification reaction or by the addition of polyols to diketene 
      acetals, and it is the latter method that has proven to be preferred one. The 
      latest polymer, now under intense development, incorporates a latent acid segment 
      in the polymer backbone that takes advantage of the acid-labile nature of the 
      ortho ester linkages and allows control over erosion rates. By use of diols 
      having selected chain flexibility, polymers that range from hard, brittle 
      materials to materials that have a gel-like consistency at room temperature can 
      be obtained. Drug release from solid materials will be illustrated with 
      5-fluorouacil and bovine serum albumin, and drug release from gel-like materials 
      will be illustrated with mepivacaine, now in Phase II clinical trials as a 
      delivery system to treat post-operative pain. A brief summary of preclinical 
      toxicology studies is also presented.
FAU - Heller, Jorge
AU  - Heller J
AD  - AP Pharma, 123 Saginaw Drive, Redwood City, California 94063, USA. 
      jorgeheller2@aol.com
FAU - Barr, John
AU  - Barr J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Biomacromolecules
JT  - Biomacromolecules
JID - 100892849
RN  - 0 (Polymers)
RN  - 0 (poly(ortho ester))
SB  - IM
MH  - Animals
MH  - Drug Delivery Systems/*methods
MH  - Humans
MH  - Pain, Postoperative/drug therapy
MH  - Polymers/*administration & dosage/*chemical synthesis
RF  - 18
EDAT- 2004/09/14 05:00
MHDA- 2005/02/23 09:00
CRDT- 2004/09/14 05:00
PHST- 2004/09/14 05:00 [pubmed]
PHST- 2005/02/23 09:00 [medline]
PHST- 2004/09/14 05:00 [entrez]
AID - 10.1021/bm040049n [doi]
PST - ppublish
SO  - Biomacromolecules. 2004 Sep-Oct;5(5):1625-32. doi: 10.1021/bm040049n.