PMID- 1538124
OWN - NLM
STAT- MEDLINE
DCOM- 19920330
LR  - 20061115
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 148
IP  - 5
DP  - 1992 Mar 1
TI  - Differential expression of transforming growth factor-beta 1, -beta 2, and -beta 
      3 by glioblastoma cells, astrocytes, and microglia.
PG  - 1404-10
AB  - The type beta transforming growth factors (TGF) are potent regulators of the 
      growth and functions of lymphocytes and macrophages. Recently the human 
      glioblastoma cell line 308 was shown to produce TGF-beta 2. The relevance of this 
      finding was evaluated further by comparing human glioblastoma cells with their 
      nontransformed animal counterpart, astrocytes, with regard to the production of 
      the three TGF-beta isoforms observed so far in mammals. In this report astrocytes 
      are demonstrated to secrete also TGF-beta 2 and to express TGF-beta 1, -beta 2, 
      and -beta 3 mRNA in vitro. In contrast, cultured murine brain macrophages release 
      TGF-beta 1 and are positive for TGF-beta 1 mRNA only. Glia cell-derived TGF-beta 
      1 and -beta 2 are detected in latent form whereas both latent and active TGF-beta 
      are identified in the supernatant of three human glioblastoma cell lines tested. 
      These cell lines, however, show heterogeneity in regard to the isoform of 
      TGF-beta expressed but share with astrocytes the inability to release TGF-beta 3. 
      Provided production and activation of latent TGF-beta occur in vivo, astrocytes 
      and microglia may then be expected to exert regulatory influences on immune 
      mediated diseases of the central nervous system.
FAU - Constam, D B
AU  - Constam DB
AD  - Department of Internal Medicine, University Hospital, Zurich, Switzerland.
FAU - Philipp, J
AU  - Philipp J
FAU - Malipiero, U V
AU  - Malipiero UV
FAU - ten Dijke, P
AU  - ten Dijke P
FAU - Schachner, M
AU  - Schachner M
FAU - Fontana, A
AU  - Fontana A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (RNA, Messenger)
RN  - 0 (Transforming Growth Factor beta)
RN  - EC 3.1.- (Ribonucleases)
SB  - IM
MH  - Animals
MH  - Astrocytes/*chemistry
MH  - Cells, Cultured
MH  - Glioma/*chemistry
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Neuroglia/*chemistry
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Ribonucleases/pharmacology
MH  - T-Lymphocytes/immunology
MH  - Transforming Growth Factor beta/*analysis/genetics
MH  - Tumor Cells, Cultured
EDAT- 1992/03/01 00:00
MHDA- 1992/03/01 00:01
CRDT- 1992/03/01 00:00
PHST- 1992/03/01 00:00 [pubmed]
PHST- 1992/03/01 00:01 [medline]
PHST- 1992/03/01 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1992 Mar 1;148(5):1404-10.