PMID- 1538783
OWN - NLM
STAT- MEDLINE
DCOM- 19920327
LR  - 20220331
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 356
IP  - 6364
DP  - 1992 Mar 5
TI  - Prevention of experimental autoimmune encephalomyelitis by antibodies against 
      alpha 4 beta 1 integrin.
PG  - 63-6
AB  - Experimental autoimmune encephalomyelitis (EAE) is an inflammatory condition of 
      the central nervous system with similarities to multiple sclerosis. In both 
      diseases, circulating leukocytes penetrate the blood-brain barrier and damage 
      myelin, resulting in impaired nerve conduction and paralysis. We sought to 
      identify the adhesion receptors that mediate the attachment of circulating 
      leukocytes to inflamed brain endothelium in EAE, because this interaction is the 
      first step in leukocyte entry into the central nervous system. Using an in vitro 
      adhesion assay on tissue sections, we found that lymphocytes and monocytes bound 
      selectively to inflamed EAE brain vessels. Binding was inhibited by antibodies 
      against the integrin molecule alpha 4 beta 1, but not by antibodies against 
      numerous other adhesion receptors. When tested in vivo, anti-alpha 4 integrin 
      effectively prevented the accumulation of leukocytes in the central nervous 
      system and the development of EAE. Thus, therapies designed to interfere with 
      alpha 4 beta 1 integrin may be useful in treating inflammatory diseases of the 
      central nervous system, such as multiple sclerosis.
FAU - Yednock, T A
AU  - Yednock TA
AD  - Athena Neurosciences, South San Francisco, California.
FAU - Cannon, C
AU  - Cannon C
FAU - Fritz, L C
AU  - Fritz LC
FAU - Sanchez-Madrid, F
AU  - Sanchez-Madrid F
FAU - Steinman, L
AU  - Steinman L
FAU - Karin, N
AU  - Karin N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Integrin alpha4beta1)
RN  - 0 (Integrins)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/immunology/*therapeutic use
MH  - Autoimmune Diseases/immunology/*prevention & control
MH  - Blood Vessels/immunology/metabolism
MH  - Brain/blood supply/immunology
MH  - Cell Adhesion
MH  - Central Nervous System/immunology
MH  - Encephalomyelitis, Autoimmune, Experimental/immunology/*prevention & control
MH  - Integrin alpha4beta1
MH  - Integrins/*immunology/metabolism
MH  - Lymphocytes/immunology/metabolism
MH  - Monocytes/immunology/metabolism
MH  - Rats
MH  - Rats, Inbred Lew
EDAT- 1992/03/05 00:00
MHDA- 1992/03/05 00:01
CRDT- 1992/03/05 00:00
PHST- 1992/03/05 00:00 [pubmed]
PHST- 1992/03/05 00:01 [medline]
PHST- 1992/03/05 00:00 [entrez]
AID - 10.1038/356063a0 [doi]
PST - ppublish
SO  - Nature. 1992 Mar 5;356(6364):63-6. doi: 10.1038/356063a0.