PMID- 15461798 OWN - NLM STAT- MEDLINE DCOM- 20050728 LR - 20240109 IS - 1474-760X (Electronic) IS - 1465-6906 (Print) IS - 1474-7596 (Linking) VI - 5 IP - 10 DP - 2004 TI - Bioconductor: open software development for computational biology and bioinformatics. PG - R80 AB - The Bioconductor project is an initiative for the collaborative creation of extensible software for computational biology and bioinformatics. The goals of the project include: fostering collaborative development and widespread use of innovative software, reducing barriers to entry into interdisciplinary scientific research, and promoting the achievement of remote reproducibility of research results. We describe details of our aims and methods, identify current challenges, compare Bioconductor to other open bioinformatics projects, and provide working examples. FAU - Gentleman, Robert C AU - Gentleman RC AD - Department of Biostatistical Science, Dana-Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA. rgentlem@jimmy.harvard.edu FAU - Carey, Vincent J AU - Carey VJ FAU - Bates, Douglas M AU - Bates DM FAU - Bolstad, Ben AU - Bolstad B FAU - Dettling, Marcel AU - Dettling M FAU - Dudoit, Sandrine AU - Dudoit S FAU - Ellis, Byron AU - Ellis B FAU - Gautier, Laurent AU - Gautier L FAU - Ge, Yongchao AU - Ge Y FAU - Gentry, Jeff AU - Gentry J FAU - Hornik, Kurt AU - Hornik K FAU - Hothorn, Torsten AU - Hothorn T FAU - Huber, Wolfgang AU - Huber W FAU - Iacus, Stefano AU - Iacus S FAU - Irizarry, Rafael AU - Irizarry R FAU - Leisch, Friedrich AU - Leisch F FAU - Li, Cheng AU - Li C FAU - Maechler, Martin AU - Maechler M FAU - Rossini, Anthony J AU - Rossini AJ FAU - Sawitzki, Gunther AU - Sawitzki G FAU - Smith, Colin AU - Smith C FAU - Smyth, Gordon AU - Smyth G FAU - Tierney, Luke AU - Tierney L FAU - Yang, Jean Y H AU - Yang JY FAU - Zhang, Jianhua AU - Zhang J LA - eng PT - Journal Article DEP - 20040915 PL - England TA - Genome Biol JT - Genome biology JID - 100960660 SB - IM MH - Computational Biology/*instrumentation/*methods MH - Internet MH - Reproducibility of Results MH - *Software PMC - PMC545600 EDAT- 2004/10/06 09:00 MHDA- 2005/07/29 09:00 PMCR- 2004/09/15 CRDT- 2004/10/06 09:00 PHST- 2004/04/19 00:00 [received] PHST- 2004/07/01 00:00 [revised] PHST- 2004/08/03 00:00 [accepted] PHST- 2004/10/06 09:00 [pubmed] PHST- 2005/07/29 09:00 [medline] PHST- 2004/10/06 09:00 [entrez] PHST- 2004/09/15 00:00 [pmc-release] AID - gb-2004-5-10-r80 [pii] AID - 10.1186/gb-2004-5-10-r80 [doi] PST - ppublish SO - Genome Biol. 2004;5(10):R80. doi: 10.1186/gb-2004-5-10-r80. Epub 2004 Sep 15.