PMID- 15466194
OWN - NLM
STAT- MEDLINE
DCOM- 20041116
LR  - 20240109
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 64
IP  - 19
DP  - 2004 Oct 1
TI  - Isolation and characterization of tumorigenic, stem-like neural precursors from 
      human glioblastoma.
PG  - 7011-21
AB  - Transformed stem cells have been isolated from some human cancers. We report 
      that, unlike other brain cancers, the lethal glioblastoma multiforme contains 
      neural precursors endowed with all of the critical features expected from neural 
      stem cells. Similar, yet not identical, to their normal neural stem cell 
      counterpart, these precursors emerge as unipotent (astroglial) in vivo and 
      multipotent (neuronal-astroglial-oligodendroglial) in culture. More importantly, 
      these cells can act as tumor-founding cells down to the clonal level and can 
      establish tumors that closely resemble the main histologic, cytologic, and 
      architectural features of the human disease, even when challenged through serial 
      transplantation. Thus, cells possessing all of the characteristics expected from 
      tumor neural stem cells seem to be involved in the growth and recurrence of adult 
      human glioblastomas multiforme.
FAU - Galli, Rossella
AU  - Galli R
AD  - Stem Cell Research Institute and Laboratory of Molecular Diagnostics, H. S. 
      Raffaele, Milan, Italy. galli.rossella@hsr.it.
FAU - Binda, Elena
AU  - Binda E
FAU - Orfanelli, Ugo
AU  - Orfanelli U
FAU - Cipelletti, Barbara
AU  - Cipelletti B
FAU - Gritti, Angela
AU  - Gritti A
FAU - De Vitis, Simona
AU  - De Vitis S
FAU - Fiocco, Roberta
AU  - Fiocco R
FAU - Foroni, Chiara
AU  - Foroni C
FAU - Dimeco, Francesco
AU  - Dimeco F
FAU - Vescovi, Angelo
AU  - Vescovi A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
SB  - IM
MH  - Adult
MH  - Animals
MH  - Brain Neoplasms/*pathology
MH  - Cell Line, Tumor
MH  - Cell Transformation, Neoplastic/pathology
MH  - Glioblastoma/*pathology
MH  - Humans
MH  - Mice
MH  - Mice, SCID
MH  - Multipotent Stem Cells/*pathology
MH  - Neoplastic Stem Cells/*pathology
MH  - Neurons/*pathology
EDAT- 2004/10/07 09:00
MHDA- 2004/11/17 09:00
CRDT- 2004/10/07 09:00
PHST- 2004/10/07 09:00 [pubmed]
PHST- 2004/11/17 09:00 [medline]
PHST- 2004/10/07 09:00 [entrez]
AID - 64/19/7011 [pii]
AID - 10.1158/0008-5472.CAN-04-1364 [doi]
PST - ppublish
SO  - Cancer Res. 2004 Oct 1;64(19):7011-21. doi: 10.1158/0008-5472.CAN-04-1364.