PMID- 15473844
OWN - NLM
STAT- MEDLINE
DCOM- 20050207
LR  - 20061115
IS  - 1081-0706 (Print)
IS  - 1081-0706 (Linking)
VI  - 20
DP  - 2004
TI  - The adenomatous polyposis coli protein: the Achilles heel of the gut epithelium.
PG  - 337-66
AB  - The Adenomatous Polyposis coli (APC) gene is mutated or lost in most colon 
      cancers, and the APC protein has emerged as a multifunctional protein that is not 
      only involved in the Wnt-regulated degradation of -catenin, but also regulates 
      cytoskeletal proteins and thus plays a role in cell migration, cell adhesion, and 
      mitosis. The gut epithelium is uniquely dependent on an intricate balance between 
      a number of fundamental cellular processes including migration, differentiation, 
      adhesion, apoptosis, and mitosis. In this review, I discuss the molecular 
      mechanisms that govern the various functions of APC and their relationship to the 
      role of APC in colon cancer.
FAU - Nathke, Inke S
AU  - Nathke IS
AD  - Cell and Developmental Biology, University of Dundee Dundee DD1 5EH, Scotland, 
      United Kingdom. i.s.nathke@dundee.ac.uk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Annu Rev Cell Dev Biol
JT  - Annual review of cell and developmental biology
JID - 9600627
RN  - 0 (Adenomatous Polyposis Coli Protein)
SB  - IM
MH  - Adenomatous Polyposis Coli Protein/analysis/*physiology
MH  - Animals
MH  - Cell Nucleus/chemistry/metabolism
MH  - Colonic Neoplasms/etiology/*metabolism
MH  - Cytoskeleton/metabolism
MH  - Gastrointestinal Tract/physiology
MH  - Intestinal Mucosa/*physiology
RF  - 157
EDAT- 2004/10/12 09:00
MHDA- 2005/02/08 09:00
CRDT- 2004/10/12 09:00
PHST- 2004/10/12 09:00 [pubmed]
PHST- 2005/02/08 09:00 [medline]
PHST- 2004/10/12 09:00 [entrez]
AID - 10.1146/annurev.cellbio.20.012103.094541 [doi]
PST - ppublish
SO  - Annu Rev Cell Dev Biol. 2004;20:337-66. doi: 
      10.1146/annurev.cellbio.20.012103.094541.