PMID- 15555009
OWN - NLM
STAT- MEDLINE
DCOM- 20041210
LR  - 20131121
IS  - 0002-9270 (Print)
IS  - 0002-9270 (Linking)
VI  - 99
IP  - 11
DP  - 2004 Nov
TI  - Pathogenesis of chronic pancreatitis: an evidence-based review of past theories 
      and recent developments.
PG  - 2256-70
AB  - In the past several decades, four prominent theories of chronic pancreatitis 
      pathogenesis have emerged: the toxic-metabolic theory, the oxidative stress 
      hypothesis, the stone and duct obstruction theory, and the necrosis-fibrosis 
      hypothesis. Although these traditional theories are formulated based on 
      compelling scientific observations, substantial contradictory data also exist for 
      each. Furthermore, the basic premises of some of these theories are directly 
      contradictory. Because of the recent scientific progress in the underlying 
      genetic, cellular, and molecular pathophysiology, there have been substantial 
      advances in the understanding of chronic pancreatitis pathogenesis. This paper 
      will provide an evidence-based review and critique of the traditional pathogenic 
      theories, followed by a discussion of the new advances in pancreatic 
      fibrogenesis. Moreover, we will discuss plausible pathogenic sequences applied to 
      each of the known etiologies.
FAU - Stevens, Tyler
AU  - Stevens T
AD  - The Pancreas Clinic, Section of Endoscopy and Pancreaticobiliary Disease, 
      Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, 
      Cleveland, Ohio 44118, USA.
FAU - Conwell, Darwin L
AU  - Conwell DL
FAU - Zuccaro, Gregory
AU  - Zuccaro G
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Am J Gastroenterol
JT  - The American journal of gastroenterology
JID - 0421030
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Animals
MH  - Calculi/complications
MH  - Chronic Disease
MH  - Constriction, Pathologic
MH  - Ethanol/toxicity
MH  - Evidence-Based Medicine
MH  - Humans
MH  - Oxidative Stress
MH  - Pancreatic Ducts/pathology
MH  - Pancreatitis/*etiology/pathology/physiopathology
RF  - 138
EDAT- 2004/11/24 09:00
MHDA- 2004/12/16 09:00
CRDT- 2004/11/24 09:00
PHST- 2004/11/24 09:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/11/24 09:00 [entrez]
AID - AJG40694 [pii]
AID - 10.1111/j.1572-0241.2004.40694.x [doi]
PST - ppublish
SO  - Am J Gastroenterol. 2004 Nov;99(11):2256-70. doi: 
      10.1111/j.1572-0241.2004.40694.x.