PMID- 15723806
OWN - NLM
STAT- MEDLINE
DCOM- 20050401
LR  - 20210103
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 22
IP  - 2
DP  - 2005 Feb
TI  - Homing phenotypes of tumor-specific CD8 T cells are predetermined at the tumor 
      site by crosspresenting APCs.
PG  - 175-84
AB  - Expression of tissue-specific homing molecules directs antigen-experienced T 
      cells to particular peripheral tissues. In studies using soluble antigens that 
      focused on skin and gut, antigen-presenting cells (APCs) within regional lymphoid 
      tissues were proposed to be responsible for imprinting homing phenotypes. Whether 
      this occurs in other sites and after physiologic antigen processing and 
      presentation is unknown. We define in vivo imprinting of distinct homing 
      phenotypes on monospecific T cells responding to antigens expressed by tumors in 
      intracerebral, subcutaneous, and intraperitoneal sites with efficient 
      brain-tropism of CD8 T cells crossprimed in the cervical lymph nodes (LNs). 
      Multiple imprinting programs could occur simultaneously in the same LN when 
      tumors were present in more than one site. Thus, the identity of the LN is not 
      paramount in determining the homing phenotype; this critical functional parameter 
      is dictated upstream at the site of antigen capture by crosspresenting APCs.
FAU - Calzascia, Thomas
AU  - Calzascia T
AD  - Laboratory of Tumour Immunology, Division of Oncology, Geneva University 
      Hospital, Rue Micheli-du-Crest 24, CH-1211 Geneva 14, Switzerland.
FAU - Masson, Frederick
AU  - Masson F
FAU - Di Berardino-Besson, Wilma
AU  - Di Berardino-Besson W
FAU - Contassot, Emmanuel
AU  - Contassot E
FAU - Wilmotte, Rick
AU  - Wilmotte R
FAU - Aurrand-Lions, Michel
AU  - Aurrand-Lions M
FAU - Ruegg, Curzio
AU  - Ruegg C
FAU - Dietrich, Pierre-Yves
AU  - Dietrich PY
FAU - Walker, Paul R
AU  - Walker PR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Cell Adhesion Molecules)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/*immunology
MH  - Antigen-Presenting Cells/*immunology
MH  - Antigens, Neoplasm/immunology
MH  - CD8-Positive T-Lymphocytes/*cytology/*immunology/metabolism
MH  - Cell Adhesion
MH  - Cell Adhesion Molecules/metabolism
MH  - Cell Line, Tumor
MH  - *Cell Movement
MH  - Central Nervous System/immunology
MH  - Mice
MH  - Mice, Transgenic
MH  - Neoplasm Transplantation
MH  - Neoplasms/*immunology/metabolism/*pathology
MH  - Phenotype
EDAT- 2005/02/23 09:00
MHDA- 2005/04/02 09:00
CRDT- 2005/02/23 09:00
PHST- 2003/12/09 00:00 [received]
PHST- 2004/12/10 00:00 [revised]
PHST- 2004/12/17 00:00 [accepted]
PHST- 2005/02/23 09:00 [pubmed]
PHST- 2005/04/02 09:00 [medline]
PHST- 2005/02/23 09:00 [entrez]
AID - S1074-7613(05)00027-0 [pii]
AID - 10.1016/j.immuni.2004.12.008 [doi]
PST - ppublish
SO  - Immunity. 2005 Feb;22(2):175-84. doi: 10.1016/j.immuni.2004.12.008.