PMID- 15731576
OWN - NLM
STAT- MEDLINE
DCOM- 20050614
LR  - 20220321
IS  - 1072-4109 (Print)
IS  - 1072-4109 (Linking)
VI  - 12
IP  - 2
DP  - 2005 Mar
TI  - Precursors to invasive pancreatic cancer.
PG  - 81-91
AB  - Pancreatic cancer, once invasive, is almost uniformly fatal. In order to 
      alleviate the dismal prognosis associated with this disease, it is imperative 
      that pancreatic cancer be recognized and treated prior to invasion. Understanding 
      the morphology and biology of precursor lesions of invasive pancreatic cancer has 
      therefore become an issue of paramount importance. In the last decade, 
      significant progress has been in the recognition and appropriate classification 
      of these precursor lesions, and the current review will focus on our 
      state-of-the-art knowledge on this topic. Mucinous cystic neoplasms (MCNs), 
      intraductal papillary mucinous neoplasms (IPMNs), and pancreatic intraepithelial 
      neoplasia (PanIN) encompass the three known morphologically distinct precursors 
      to invasive pancreatic cancer. In addition to discussion of the "classic" 
      precursor entities, this review will also address some of the recent diagnostic 
      controversies for these lesions, in particular features that distinguish IPMNs 
      from PanIN lesions. Finally, the potential clinical impact of recognizing these 
      precursor lesions in the context of early detection of pancreatic cancer will be 
      discussed.
FAU - Maitra, Anirban
AU  - Maitra A
AD  - Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns 
      Hopkins Medical Institutions, Baltimore, Maryland 21231-2410, USA.
FAU - Fukushima, Noriyoshi
AU  - Fukushima N
FAU - Takaori, Kyoichi
AU  - Takaori K
FAU - Hruban, Ralph H
AU  - Hruban RH
LA  - eng
GR  - P50-CA-62924/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Adv Anat Pathol
JT  - Advances in anatomic pathology
JID - 9435676
SB  - IM
MH  - Adenocarcinoma, Mucinous/genetics/*pathology
MH  - Adenocarcinoma, Papillary/genetics/*pathology
MH  - Animals
MH  - Carcinoma in Situ/genetics/*pathology
MH  - Carcinoma, Pancreatic Ductal/genetics/*pathology
MH  - Disease Models, Animal
MH  - Humans
MH  - Molecular Biology
MH  - Pancreatic Neoplasms/genetics/*pathology
RF  - 123
EDAT- 2005/02/26 09:00
MHDA- 2005/06/15 09:00
CRDT- 2005/02/26 09:00
PHST- 2005/02/26 09:00 [pubmed]
PHST- 2005/06/15 09:00 [medline]
PHST- 2005/02/26 09:00 [entrez]
AID - 00125480-200503000-00006 [pii]
AID - 10.1097/01.pap.0000155055.14238.25 [doi]
PST - ppublish
SO  - Adv Anat Pathol. 2005 Mar;12(2):81-91. doi: 10.1097/01.pap.0000155055.14238.25.