PMID- 15733314
OWN - NLM
STAT- MEDLINE
DCOM- 20050707
LR  - 20061115
IS  - 1520-541X (Print)
IS  - 1520-541X (Linking)
VI  - 7
IP  - 2
DP  - 2005 Mar-Apr
TI  - Expression of Pax group III genes suggests a single-segmental periodicity for 
      opisthosomal segment patterning in the spider Cupiennius salei.
PG  - 160-9
AB  - Pair-rule patterning forms a key step for segmentation in insects. The expression 
      patterns of pair-rule gene orthologs in representatives of other arthropod groups 
      imply that these genes were segmentation genes in the last common ancestor of the 
      various arthropod groups, but almost nothing is known about the underlying 
      mechanism in noninsect arthropods. Here, we cloned and analyzed members of the 
      Pax group III genes from the spider Cupiennius salei. Pax group III genes 
      comprise genes like the Drosophila genes paired, gooseberry, and 
      gooseberry-neuro, as well as the vertebrate Pax 3 and Pax 7 genes. We recovered 
      three Pax group III genes from the spider C. salei, Cs-pairberry-1, 
      Cs-pairberry-2, and Cs-pairberry-3, and show that the combined expression of the 
      three spider genes mimics the patterns in insects, suggesting an ancestral role 
      for Pax group III genes in segmentation, neurogenesis, and appendage formation in 
      arthropods. One of the genes, pairberry-3, is expressed in a segmental 
      periodicity before overt morphological segmentation is visible, suggesting a 
      single segmental periodicity for opisthosomal segment pattering in the spider. 
      Comparisons among arthropods suggest that the underlying mechanisms for pair-rule 
      gene orthologs are more diverged than the ones for the segment-polarity genes. We 
      argue that there may be a correlation between the lower variation in patterns of 
      segment-polarity genes and the phylotypic stage. The segment-polarity genes are 
      required to define the segment borders of the embryo at the germ-band stage, the 
      arthropod phylotypic stage. Pair-rule gene orthologs act more upstream and may 
      display more variation in their action.
FAU - Schoppmeier, Michael
AU  - Schoppmeier M
AD  - Institute for Genetics, Department for Evolutionary Genetics, University of 
      Cologne, Weyertal 121, D-50931 Koln, Germany.
FAU - Damen, Wim G M
AU  - Damen WG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Evol Dev
JT  - Evolution & development
JID - 100883432
RN  - 0 (Trans-Activators)
SB  - IM
MH  - Animals
MH  - Body Patterning/genetics/*physiology
MH  - Gene Expression Regulation, Developmental/genetics/*physiology
MH  - Spiders/cytology/*embryology/genetics
MH  - Trans-Activators/*biosynthesis
EDAT- 2005/03/01 09:00
MHDA- 2005/07/08 09:00
CRDT- 2005/03/01 09:00
PHST- 2005/03/01 09:00 [pubmed]
PHST- 2005/07/08 09:00 [medline]
PHST- 2005/03/01 09:00 [entrez]
AID - EDE05018 [pii]
AID - 10.1111/j.1525-142X.2005.05018.x [doi]
PST - ppublish
SO  - Evol Dev. 2005 Mar-Apr;7(2):160-9. doi: 10.1111/j.1525-142X.2005.05018.x.