PMID- 15829953
OWN - NLM
STAT- MEDLINE
DCOM- 20050426
LR  - 20231120
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 434
IP  - 7035
DP  - 2005 Apr 14
TI  - Wnt signalling in stem cells and cancer.
PG  - 843-50
AB  - The canonical Wnt cascade has emerged as a critical regulator of stem cells. In 
      many tissues, activation of Wnt signalling has also been associated with cancer. 
      This has raised the possibility that the tightly regulated self-renewal mediated 
      by Wnt signalling in stem and progenitor cells is subverted in cancer cells to 
      allow malignant proliferation. Insights gained from understanding how the Wnt 
      pathway is integrally involved in both stem cell and cancer cell maintenance and 
      growth in the intestinal, epidermal and haematopoietic systems may serve as a 
      paradigm for understanding the dual nature of self-renewal signals.
FAU - Reya, Tannishtha
AU  - Reya T
AD  - Department of Pharmacology and Cancer Biology, Duke University Medical Center, 
      Durham, North Carolina 27710, USA. t.reya@duke.edu
FAU - Clevers, Hans
AU  - Clevers H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Wnt Proteins)
SB  - IM
MH  - Animals
MH  - Hematopoietic Stem Cells/metabolism/pathology
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*metabolism
MH  - Neoplasms/*metabolism/pathology
MH  - *Signal Transduction
MH  - Stem Cells/*metabolism/pathology
MH  - Wnt Proteins
RF  - 90
EDAT- 2005/04/15 09:00
MHDA- 2005/04/27 09:00
CRDT- 2005/04/15 09:00
PHST- 2005/04/15 09:00 [pubmed]
PHST- 2005/04/27 09:00 [medline]
PHST- 2005/04/15 09:00 [entrez]
AID - nature03319 [pii]
AID - 10.1038/nature03319 [doi]
PST - ppublish
SO  - Nature. 2005 Apr 14;434(7035):843-50. doi: 10.1038/nature03319.