PMID- 15959903
OWN - NLM
STAT- MEDLINE
DCOM- 20051107
LR  - 20220309
IS  - 0360-4012 (Print)
IS  - 0360-4012 (Linking)
VI  - 81
IP  - 3
DP  - 2005 Aug 1
TI  - Microglia function in brain tumors.
PG  - 447-55
AB  - Microglia play an important role in inflammatory diseases of the central nervous 
      system (CNS). These cells have also been identified in brain neoplasms; however, 
      as of yet their function largely remains unclear. More recent studies designed to 
      characterize further tumor-associated microglia suggest that the immune effector 
      function of these cells may be suppressed in CNS tumors. Furthermore, microglia 
      and macrophages can secrete various cytokines and growth factors that may 
      contribute to the successful immune evasion, growth, and invasion of brain 
      neoplasms. A better understanding of microglia and macrophage function is 
      essential for the development of immune-based treatment strategies against 
      malignant brain tumors.
CI  - (c) 2005 Wiley-Liss, Inc.
FAU - Watters, Jyoti J
AU  - Watters JJ
AD  - Department of Comparative Biosciences, School of Veterinary Medicine, University 
      of Wisconsin, Madison, Wisconsin 53792-3232, USA.
FAU - Schartner, Jill M
AU  - Schartner JM
FAU - Badie, Behnam
AU  - Badie B
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Antigen-Presenting Cells/pathology/physiology
MH  - Brain Neoplasms/*pathology
MH  - Cell Communication
MH  - Cell Movement
MH  - Cell Proliferation
MH  - Cytokines/metabolism
MH  - Glioma/physiopathology
MH  - Humans
MH  - Immune Tolerance/physiology
MH  - Microglia/*pathology
MH  - Neovascularization, Pathologic
RF  - 103
EDAT- 2005/06/17 09:00
MHDA- 2005/11/08 09:00
CRDT- 2005/06/17 09:00
PHST- 2005/06/17 09:00 [pubmed]
PHST- 2005/11/08 09:00 [medline]
PHST- 2005/06/17 09:00 [entrez]
AID - 10.1002/jnr.20485 [doi]
PST - ppublish
SO  - J Neurosci Res. 2005 Aug 1;81(3):447-55. doi: 10.1002/jnr.20485.