PMID- 16002658
OWN - NLM
STAT- MEDLINE
DCOM- 20050927
LR  - 20190516
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 175
IP  - 2
DP  - 2005 Jul 15
TI  - Cutting edge: IL-12 induces CD4+CD25- T cell activation in the presence of T 
      regulatory cells.
PG  - 641-5
AB  - IL-12p40 cytokines have been implicated in the development of organ-specific 
      autoimmune diseases as well as pathogen-specific adaptive immunity. In addition 
      to inducing IFN-gamma, IL-12 stimulates effector CD4(+) T cells to express 
      adhesion molecules and homing receptors that facilitate their migration to sites 
      of inflammation. In this study, we expand upon those observations by 
      demonstrating an alternative pathway by which IL-12 could promote Th1 
      inflammatory responses in mice, namely, by restoring proliferation and cytokine 
      expression by effector T cells in the presence of CD4(+)CD25(+) regulatory T 
      cells (Treg). This effect of IL-12 was not replicated by IL-23 or IFN-gamma and 
      was dependent on signaling through the IL-12R expressed on CD25(-) responder 
      cells, but not on Treg. Our studies suggest that IL-12 could act in concert with 
      other proinflammatory factors to stimulate CD4(+)CD25(-) T cell activation in the 
      presence of Treg.
FAU - King, Irah L
AU  - King IL
AD  - Interdepartmental Graduate Program in Neuroscience, Department of Neurology, 
      University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, 
      Rochester, NY 14642, USA.
FAU - Segal, Benjamin M
AU  - Segal BM
LA  - eng
GR  - NS 147687-01A1/NS/NINDS NIH HHS/United States
GR  - NS 41562/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Il23a protein, mouse)
RN  - 0 (Interleukin-2)
RN  - 0 (Interleukin-23)
RN  - 0 (Interleukin-23 Subunit p19)
RN  - 0 (Interleukins)
RN  - 0 (Protein Subunits)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Interleukin)
RN  - 0 (Receptors, Interleukin-12)
RN  - 0 (Receptors, Interleukin-2)
RN  - 187348-17-0 (Interleukin-12)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/*immunology/metabolism
MH  - Cell Proliferation
MH  - Cells, Cultured
MH  - Coculture Techniques
MH  - Interferon-gamma/physiology
MH  - Interleukin-12/*physiology
MH  - Interleukin-2/biosynthesis/genetics
MH  - Interleukin-23
MH  - Interleukin-23 Subunit p19
MH  - Interleukins/physiology
MH  - Lymphocyte Activation/*immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Protein Subunits/physiology
MH  - RNA, Messenger/biosynthesis/metabolism
MH  - Receptors, Interleukin/deficiency/genetics
MH  - Receptors, Interleukin-12
MH  - *Receptors, Interleukin-2/biosynthesis
MH  - T-Lymphocytes, Regulatory/*immunology/metabolism
EDAT- 2005/07/09 09:00
MHDA- 2005/09/28 09:00
CRDT- 2005/07/09 09:00
PHST- 2005/07/09 09:00 [pubmed]
PHST- 2005/09/28 09:00 [medline]
PHST- 2005/07/09 09:00 [entrez]
AID - 175/2/641 [pii]
AID - 10.4049/jimmunol.175.2.641 [doi]
PST - ppublish
SO  - J Immunol. 2005 Jul 15;175(2):641-5. doi: 10.4049/jimmunol.175.2.641.