PMID- 16039904
OWN - NLM
STAT- MEDLINE
DCOM- 20060106
LR  - 20071114
IS  - 1471-4906 (Print)
IS  - 1471-4906 (Linking)
VI  - 26
IP  - 9
DP  - 2005 Sep
TI  - The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and 
      molecular mechanisms.
PG  - 485-95
AB  - This review addresses current knowledge of the molecular trafficking signals 
      involved in the migration of circulating leukocytes across the highly specialized 
      blood-central nervous system (CNS) barriers during immunosurveillance and 
      inflammation. In this regard, adhesion molecules and activating and chemotactic 
      factors are also discussed and the regional variability in the brain and spinal 
      cord parenchyma are also considered. Furthermore, direct passage into 
      cerebrospinal fluid (CSF) is discussed, in the context of CNS immunosurveillance. 
      The potential differences that characterize leukocyte entry into these varied 
      anatomical sites are highlighted, with special emphasis on studies of the 
      pathogenesis of multiple sclerosis and its animal models. An update on findings 
      from clinical trials of natalizumab is also provided.
FAU - Engelhardt, Britta
AU  - Engelhardt B
AD  - Theodor Kocher Institute, University of Bern, CH-3012 Bern, Switzerland. 
      bengel@tki.unibe.ch
FAU - Ransohoff, Richard M
AU  - Ransohoff RM
LA  - eng
GR  - NS32151/NS/NINDS NIH HHS/United States
GR  - NS36674/NS/NINDS NIH HHS/United States
GR  - NS38677/NS/NINDS NIH HHS/United States
GR  - TW6012/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
SB  - IM
MH  - Animals
MH  - Central Nervous System/anatomy & histology/*immunology
MH  - Humans
MH  - Models, Immunological
MH  - T-Lymphocytes/*immunology
RF  - 99
EDAT- 2005/07/26 09:00
MHDA- 2006/01/07 09:00
CRDT- 2005/07/26 09:00
PHST- 2005/03/29 00:00 [received]
PHST- 2005/06/02 00:00 [revised]
PHST- 2005/07/07 00:00 [accepted]
PHST- 2005/07/26 09:00 [pubmed]
PHST- 2006/01/07 09:00 [medline]
PHST- 2005/07/26 09:00 [entrez]
AID - S1471-4906(05)00183-3 [pii]
AID - 10.1016/j.it.2005.07.004 [doi]
PST - ppublish
SO  - Trends Immunol. 2005 Sep;26(9):485-95. doi: 10.1016/j.it.2005.07.004.