PMID- 16168650
OWN - NLM
STAT- MEDLINE
DCOM- 20051223
LR  - 20220408
IS  - 0960-894X (Print)
IS  - 0960-894X (Linking)
VI  - 15
IP  - 22
DP  - 2005 Nov 15
TI  - Synthesis of doxorubicin-peptide conjugate with multidrug resistant tumor cell 
      killing activity.
PG  - 5071-5
AB  - Cell penetrating peptide TAT was introduced into doxorubicin structure. 
      Synthesized doxorubicin-TAT conjugate showed different intracellular distribution 
      pattern and cell killing activity from those of free doxorubicin. Unlike free 
      doxorubicin, doxorubicin-TAT conjugate was highly permeable to drug-resistant 
      cells and was able to kill drug-resistant tumor cells efficiently.
FAU - Liang, Jun F
AU  - Liang JF
AD  - Department of Chemistry and Chemical Biology, Stevens Institute of Technology, 
      Hoboken, NJ 07030, USA. jliang2@stevens.edu
FAU - Yang, Victor C
AU  - Yang VC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Bioorg Med Chem Lett
JT  - Bioorganic & medicinal chemistry letters
JID - 9107377
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Peptides)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Antineoplastic Agents/*chemical synthesis/chemistry/*pharmacology
MH  - Cell Line, Tumor
MH  - Cell Membrane Permeability/drug effects
MH  - Cell Proliferation/drug effects
MH  - Doxorubicin/*chemistry/*pharmacology
MH  - *Drug Resistance, Multiple
MH  - Humans
MH  - Molecular Sequence Data
MH  - Molecular Structure
MH  - Neoplasms/*pathology
MH  - Peptides/chemical synthesis/*chemistry/pharmacology
EDAT- 2005/09/20 09:00
MHDA- 2005/12/24 09:00
CRDT- 2005/09/20 09:00
PHST- 2005/06/29 00:00 [received]
PHST- 2005/07/22 00:00 [revised]
PHST- 2005/07/25 00:00 [accepted]
PHST- 2005/09/20 09:00 [pubmed]
PHST- 2005/12/24 09:00 [medline]
PHST- 2005/09/20 09:00 [entrez]
AID - S0960-894X(05)00984-4 [pii]
AID - 10.1016/j.bmcl.2005.07.087 [doi]
PST - ppublish
SO  - Bioorg Med Chem Lett. 2005 Nov 15;15(22):5071-5. doi: 10.1016/j.bmcl.2005.07.087.