PMID- 16333296
OWN - NLM
STAT- MEDLINE
DCOM- 20060209
LR  - 20220410
IS  - 1087-0156 (Print)
IS  - 1087-0156 (Linking)
VI  - 23
IP  - 12
DP  - 2005 Dec
TI  - Designing dendrimers for biological applications.
PG  - 1517-26
AB  - Dendrimers are branched, synthetic polymers with layered architectures that show 
      promise in several biomedical applications. By regulating dendrimer synthesis, it 
      is possible to precisely manipulate both their molecular weight and chemical 
      composition, thereby allowing predictable tuning of their biocompatibility and 
      pharmacokinetics. Advances in our understanding of the role of molecular weight 
      and architecture on the in vivo behavior of dendrimers, together with recent 
      progress in the design of biodegradable chemistries, has enabled the application 
      of these branched polymers as anti-viral drugs, tissue repair scaffolds, targeted 
      carriers of chemotherapeutics and optical oxygen sensors. Before such products 
      can reach the market, however, the field must not only address the cost of 
      manufacture and quality control of pharmaceutical-grade materials, but also 
      assess the long-term human and environmental health consequences of dendrimer 
      exposure in vivo.
FAU - Lee, Cameron C
AU  - Lee CC
AD  - Department of Chemistry, University of California, Berkeley, California 
      94720-1460, USA.
FAU - MacKay, John A
AU  - MacKay JA
FAU - Frechet, Jean M J
AU  - Frechet JM
FAU - Szoka, Francis C
AU  - Szoka FC
LA  - eng
GR  - R01 CA107268/CA/NCI NIH HHS/United States
GR  - R01 EB002047/EB/NIBIB NIH HHS/United States
GR  - EB 002047/EB/NIBIB NIH HHS/United States
GR  - GM 65361/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Nat Biotechnol
JT  - Nature biotechnology
JID - 9604648
RN  - 0 (Biocompatible Materials)
RN  - 0 (Polymers)
SB  - IM
MH  - Biocompatible Materials/*chemistry
MH  - Biology/*methods
MH  - Drug Delivery Systems/*methods
MH  - *Drug Design
MH  - Gene Transfer Techniques
MH  - Guided Tissue Regeneration/*methods
MH  - Materials Testing
MH  - Polymers/*chemistry
MH  - Tissue Engineering/*methods
MH  - Transfection/methods
RF  - 94
EDAT- 2005/12/08 09:00
MHDA- 2006/02/10 09:00
CRDT- 2005/12/08 09:00
PHST- 2005/12/08 09:00 [pubmed]
PHST- 2006/02/10 09:00 [medline]
PHST- 2005/12/08 09:00 [entrez]
AID - nbt1171 [pii]
AID - 10.1038/nbt1171 [doi]
PST - ppublish
SO  - Nat Biotechnol. 2005 Dec;23(12):1517-26. doi: 10.1038/nbt1171.