PMID- 16336415
OWN - NLM
STAT- MEDLINE
DCOM- 20060209
LR  - 20061115
IS  - 1520-541X (Print)
IS  - 1520-541X (Linking)
VI  - 7
IP  - 6
DP  - 2005 Nov-Dec
TI  - Pair rule gene orthologs in spider segmentation.
PG  - 618-28
AB  - The activation of pair rule genes is the first indication of the metameric 
      organization of the Drosophila embryo and thus forms a key step in the 
      segmentation process. There are two classes of pair rule genes in Drosophila: the 
      primary pair rule genes that are directly activated by the maternal and gap genes 
      and the secondary pair rule genes that rely on input from the primary pair rule 
      genes. Here we analyze orthologs of Drosophila primary and secondary pair rule 
      orthologs in the spider Cupiennius salei. The expression patterns of the spider 
      pair rule gene orthologs can be subdivided in three groups: even-skipped and 
      runt-1 expression is in stripes that start at the posterior end of the growth 
      zone and their expression ends before the stripes reach the anterior end of the 
      growth zone, while hairy and pairberry-3 stripes also start at the posterior end, 
      but do not cease in the anterior growth zone. Stripes of odd-paired, 
      odd-skipped-related-1, and sloppy paired are only found in the anterior portion 
      of the growth zone. The various genes thus seem to be active during different 
      phases of segment specification. It is notable that the spider orthologs of the 
      Drosophila primary pair rule genes are active more posterior in the growth zone 
      and thus during earlier phases of segment specification than most orthologs of 
      Drosophila secondary pair rule genes, indicating that parts of the hierarchy 
      might be conserved between flies and spiders. The spider ortholog of the 
      Drosophila pair rule gene fushi tarazu is not expressed in the growth zone, but 
      is expressed in a Hox-like fashion. The segmentation function of fushi tarazu 
      thus appears to be a newly acquired role of the gene in the lineage of the 
      mandibulate arthropods.
FAU - Damen, Wim G M
AU  - Damen WG
AD  - Department for Evolutionary Genetics, Institute for Genetics, University of 
      Cologne, Zulpicher Str. 47, D-50674 Koln, Germany. damen@uni-koeln.de
FAU - Janssen, Ralf
AU  - Janssen R
FAU - Prpic, Nikola-Michael
AU  - Prpic NM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Evol Dev
JT  - Evolution & development
JID - 100883432
RN  - 0 (Homeodomain Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Body Patterning/*physiology
MH  - Drosophila/embryology/genetics
MH  - Gene Expression Regulation, Developmental/*physiology
MH  - Homeodomain Proteins/genetics/*metabolism
MH  - Molecular Sequence Data
MH  - *Phylogeny
MH  - Sequence Homology, Amino Acid
MH  - Spiders/cytology/*embryology/genetics
EDAT- 2005/12/13 09:00
MHDA- 2006/02/10 09:00
CRDT- 2005/12/13 09:00
PHST- 2005/12/13 09:00 [pubmed]
PHST- 2006/02/10 09:00 [medline]
PHST- 2005/12/13 09:00 [entrez]
AID - EDE05065 [pii]
AID - 10.1111/j.1525-142X.2005.05065.x [doi]
PST - ppublish
SO  - Evol Dev. 2005 Nov-Dec;7(6):618-28. doi: 10.1111/j.1525-142X.2005.05065.x.