PMID- 16341207
OWN - NLM
STAT- MEDLINE
DCOM- 20060216
LR  - 20211203
IS  - 1465-7392 (Print)
IS  - 1465-7392 (Linking)
VI  - 8
IP  - 1
DP  - 2006 Jan
TI  - The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling 
      to regulate cell proliferation and apoptosis.
PG  - 27-36
AB  - Merlin, the protein product of the Neurofibromatosis type-2 gene, acts as a 
      tumour suppressor in mice and humans. Merlin is an adaptor protein with a FERM 
      domain and it is thought to transduce a growth-regulatory signal. However, the 
      pathway through which Merlin acts as a tumour suppressor is poorly understood. 
      Merlin, and its function as a negative regulator of growth, is conserved in 
      Drosophila, where it functions with Expanded, a related FERM domain protein. 
      Here, we show that Drosophila Merlin and Expanded are components of the Hippo 
      signalling pathway, an emerging tumour-suppressor pathway. We find that Merlin 
      and Expanded, similar to other components of the Hippo pathway, are required for 
      proliferation arrest and apoptosis in developing imaginal discs. Our genetic and 
      biochemical data place Merlin and Expanded upstream of Hippo and identify a 
      pathway through which they act as tumour-suppressor genes.
FAU - Hamaratoglu, Fisun
AU  - Hamaratoglu F
AD  - Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, 
      USA.
FAU - Willecke, Maria
AU  - Willecke M
FAU - Kango-Singh, Madhuri
AU  - Kango-Singh M
FAU - Nolo, Riitta
AU  - Nolo R
FAU - Hyun, Eric
AU  - Hyun E
FAU - Tao, Chunyao
AU  - Tao C
FAU - Jafar-Nejad, Hamed
AU  - Jafar-Nejad H
FAU - Halder, Georg
AU  - Halder G
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20051211
PL  - England
TA  - Nat Cell Biol
JT  - Nature cell biology
JID - 100890575
RN  - 0 (Cyclin E)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (YAP-Signaling Proteins)
RN  - 0 (Yki protein, Drosophila)
RN  - 0 (ex protein, Drosophila)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.- (wts protein, Drosophila)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (hpo protein, Drosophila)
SB  - IM
EIN - Nat Cell Biol. 2006 Jan;8(1):100
MH  - Animals
MH  - *Apoptosis
MH  - Cell Cycle
MH  - *Cell Proliferation
MH  - Cyclin E/metabolism
MH  - Drosophila/*metabolism
MH  - Drosophila Proteins/chemistry/*genetics/*metabolism/physiology
MH  - *Genes, Neurofibromatosis 2
MH  - Intracellular Signaling Peptides and Proteins
MH  - Male
MH  - Membrane Proteins/*genetics/physiology
MH  - Mutation
MH  - Nuclear Proteins/metabolism
MH  - Protein Kinases/metabolism
MH  - Protein Serine-Threonine Kinases/chemistry/*metabolism
MH  - Signal Transduction
MH  - Trans-Activators/metabolism
MH  - Transcriptional Activation
MH  - YAP-Signaling Proteins
EDAT- 2005/12/13 09:00
MHDA- 2006/02/17 09:00
CRDT- 2005/12/13 09:00
PHST- 2005/10/27 00:00 [received]
PHST- 2005/11/17 00:00 [accepted]
PHST- 2005/12/13 09:00 [pubmed]
PHST- 2006/02/17 09:00 [medline]
PHST- 2005/12/13 09:00 [entrez]
AID - ncb1339 [pii]
AID - 10.1038/ncb1339 [doi]
PST - ppublish
SO  - Nat Cell Biol. 2006 Jan;8(1):27-36. doi: 10.1038/ncb1339. Epub 2005 Dec 11.