PMID- 16341222
OWN - NLM
STAT- MEDLINE
DCOM- 20060307
LR  - 20220309
IS  - 1061-4036 (Print)
IS  - 1061-4036 (Linking)
VI  - 38
IP  - 1
DP  - 2006 Jan
TI  - Defective planar cell polarity in polycystic kidney disease.
PG  - 21-3
AB  - Morphogenesis involves coordinated proliferation, differentiation and spatial 
      distribution of cells. We show that lengthening of renal tubules is associated 
      with mitotic orientation of cells along the tubule axis, demonstrating intrinsic 
      planar cell polarization, and we demonstrate that mitotic orientations are 
      significantly distorted in rodent polycystic kidney models. These results suggest 
      that oriented cell division dictates the maintenance of constant tubule diameter 
      during tubular lengthening and that defects in this process trigger renal tubular 
      enlargement and cyst formation.
FAU - Fischer, Evelyne
AU  - Fischer E
AD  - Gene Expression and Disease Unit, Centre National de la Recherche Scientifique 
      (CNRS) FRE 2850, Pasteur Institute, 25 rue du Docteur Roux, 75724 Paris Cedex 15, 
      France.
FAU - Legue, Emilie
AU  - Legue E
FAU - Doyen, Antonia
AU  - Doyen A
FAU - Nato, Faridabano
AU  - Nato F
FAU - Nicolas, Jean-Francois
AU  - Nicolas JF
FAU - Torres, Vicente
AU  - Torres V
FAU - Yaniv, Moshe
AU  - Yaniv M
FAU - Pontoglio, Marco
AU  - Pontoglio M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051211
PL  - United States
TA  - Nat Genet
JT  - Nature genetics
JID - 9216904
RN  - 0 (Mucoproteins)
RN  - 0 (Umod protein, mouse)
RN  - 0 (Uromodulin)
RN  - 094ZI81Y45 (Tamoxifen)
RN  - 138674-15-4 (Hepatocyte Nuclear Factor 1-beta)
SB  - IM
MH  - Animals
MH  - *Cell Polarity
MH  - Disease Models, Animal
MH  - Hepatocyte Nuclear Factor 1-beta/genetics
MH  - Kidney Tubules/drug effects/*pathology
MH  - Mice
MH  - Mice, Mutant Strains
MH  - Mitosis
MH  - Mucoproteins/metabolism
MH  - Polycystic Kidney Diseases/genetics/*pathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spindle Apparatus/physiology
MH  - Tamoxifen/pharmacology
MH  - Uromodulin
EDAT- 2005/12/13 09:00
MHDA- 2006/03/08 09:00
CRDT- 2005/12/13 09:00
PHST- 2005/09/26 00:00 [received]
PHST- 2005/10/20 00:00 [accepted]
PHST- 2005/12/13 09:00 [pubmed]
PHST- 2006/03/08 09:00 [medline]
PHST- 2005/12/13 09:00 [entrez]
AID - ng1701 [pii]
AID - 10.1038/ng1701 [doi]
PST - ppublish
SO  - Nat Genet. 2006 Jan;38(1):21-3. doi: 10.1038/ng1701. Epub 2005 Dec 11.