PMID- 16381885
OWN - NLM
STAT- MEDLINE
DCOM- 20060228
LR  - 20220408
IS  - 1362-4962 (Electronic)
IS  - 0305-1048 (Print)
IS  - 0305-1048 (Linking)
VI  - 34
IP  - Database issue
DP  - 2006 Jan 1
TI  - From genomics to chemical genomics: new developments in KEGG.
PG  - D354-7
AB  - The increasing amount of genomic and molecular information is the basis for 
      understanding higher-order biological systems, such as the cell and the organism, 
      and their interactions with the environment, as well as for medical, industrial 
      and other practical applications. The KEGG resource (http://www.genome.jp/kegg/) 
      provides a reference knowledge base for linking genomes to biological systems, 
      categorized as building blocks in the genomic space (KEGG GENES) and the chemical 
      space (KEGG LIGAND), and wiring diagrams of interaction networks and reaction 
      networks (KEGG PATHWAY). A fourth component, KEGG BRITE, has been formally added 
      to the KEGG suite of databases. This reflects our attempt to computerize 
      functional interpretations as part of the pathway reconstruction process based on 
      the hierarchically structured knowledge about the genomic, chemical and network 
      spaces. In accordance with the new chemical genomics initiatives, the scope of 
      KEGG LIGAND has been significantly expanded to cover both endogenous and 
      exogenous molecules. Specifically, RPAIR contains curated chemical structure 
      transformation patterns extracted from known enzymatic reactions, which would 
      enable analysis of genome-environment interactions, such as the prediction of new 
      reactions and new enzyme genes that would degrade new environmental compounds. 
      Additionally, drug information is now stored separately and linked to new KEGG 
      DRUG structure maps.
FAU - Kanehisa, Minoru
AU  - Kanehisa M
AD  - Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, 
      Kyoto 611-0011, Japan. kanehisa@kuicr.kyoto-u.ac.jp
FAU - Goto, Susumu
AU  - Goto S
FAU - Hattori, Masahiro
AU  - Hattori M
FAU - Aoki-Kinoshita, Kiyoko F
AU  - Aoki-Kinoshita KF
FAU - Itoh, Masumi
AU  - Itoh M
FAU - Kawashima, Shuichi
AU  - Kawashima S
FAU - Katayama, Toshiaki
AU  - Katayama T
FAU - Araki, Michihiro
AU  - Araki M
FAU - Hirakawa, Mika
AU  - Hirakawa M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nucleic Acids Res
JT  - Nucleic acids research
JID - 0411011
RN  - 0 (Enzymes)
RN  - 0 (Ligands)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - *Biotransformation
MH  - Chemical Phenomena
MH  - *Chemistry
MH  - *Databases, Factual
MH  - *Databases, Genetic
MH  - Environment
MH  - Enzymes/chemistry/genetics
MH  - *Genomics
MH  - Humans
MH  - Internet
MH  - Ligands
MH  - Pharmaceutical Preparations/chemistry/classification
MH  - Signal Transduction
MH  - Systems Integration
MH  - User-Computer Interface
PMC - PMC1347464
EDAT- 2005/12/31 09:00
MHDA- 2006/03/01 09:00
PMCR- 2005/12/28
CRDT- 2005/12/31 09:00
PHST- 2005/12/31 09:00 [pubmed]
PHST- 2006/03/01 09:00 [medline]
PHST- 2005/12/31 09:00 [entrez]
PHST- 2005/12/28 00:00 [pmc-release]
AID - 34/suppl_1/D354 [pii]
AID - 10.1093/nar/gkj102 [doi]
PST - ppublish
SO  - Nucleic Acids Res. 2006 Jan 1;34(Database issue):D354-7. doi: 10.1093/nar/gkj102.