PMID- 16585184
OWN - NLM
STAT- MEDLINE
DCOM- 20060522
LR  - 20220408
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 66
IP  - 7
DP  - 2006 Apr 1
TI  - FoxM1B is overexpressed in human glioblastomas and critically regulates the 
      tumorigenicity of glioma cells.
PG  - 3593-602
AB  - The transcription factor Forkhead box M1 (FoxM1) is overexpressed in malignant 
      glioma. However, the functional importance of this factor in human glioma is not 
      known. In the present study, we found that FoxM1B was the predominant FoxM1 
      isoform expressed in human glioma but not in normal brain tissue. The level of 
      FoxM1 protein expression in human glioma tissues was directly correlated with the 
      glioma grade. The level of FoxM1 protein expression in human glioblastoma tissues 
      was inversely correlated with patient survival. Enforced FoxM1B expression caused 
      SW1783 and Hs683 glioma cells, which do not form tumor xenografts, to regain 
      tumorigenicity in nude mouse model systems. Moreover, gliomas that arose from 
      FoxM1B-transfected anaplastic astrocytoma SW1783 cells displayed glioblastoma 
      multiforme phenotypes. Inhibition of FoxM1 expression in glioblastoma U-87MG 
      cells suppressed their anchorage-independent growth in vitro and tumorigenicity 
      in vivo. Furthermore, we found that FoxM1 regulates the expression of Skp2 
      protein, which is known to promote degradation of the cell cycle regulator 
      p27(Kip1). These results showed that FoxM1 is overexpressed in human 
      glioblastomas and contributes to glioma tumorigenicity. Therefore, FoxM1 might be 
      a new potential target of therapy for human malignant gliomas.
FAU - Liu, Mingguang
AU  - Liu M
AD  - Department of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, 
      1515 Holcombe Boulevard, Houston, TX 77030, USA.
FAU - Dai, Bingbing
AU  - Dai B
FAU - Kang, Shin-Hyuk
AU  - Kang SH
FAU - Ban, Kechen
AU  - Ban K
FAU - Huang, Feng-Ju
AU  - Huang FJ
FAU - Lang, Frederick F
AU  - Lang FF
FAU - Aldape, Kenneth D
AU  - Aldape KD
FAU - Xie, Tong-xin
AU  - Xie TX
FAU - Pelloski, Christopher E
AU  - Pelloski CE
FAU - Xie, Keping
AU  - Xie K
FAU - Sawaya, Raymond
AU  - Sawaya R
FAU - Huang, Suyun
AU  - Huang S
LA  - eng
GR  - CA 16672/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Forkhead Box Protein M1)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxm1 protein, mouse)
RN  - 0 (Protein Isoforms)
RN  - 0 (RNA, Messenger)
RN  - 0 (S-Phase Kinase-Associated Proteins)
RN  - 136601-57-5 (Cyclin D1)
RN  - 147604-94-2 (Cyclin-Dependent Kinase Inhibitor p27)
SB  - IM
MH  - Animals
MH  - Astrocytoma/genetics/*metabolism/*pathology
MH  - Brain Neoplasms/genetics/*metabolism/*pathology
MH  - Cell Line, Tumor
MH  - Cyclin D1/metabolism
MH  - Cyclin-Dependent Kinase Inhibitor p27/metabolism
MH  - Forkhead Box Protein M1
MH  - Forkhead Transcription Factors/antagonists & inhibitors/*biosynthesis/genetics
MH  - Glioblastoma/genetics/*metabolism/*pathology
MH  - Humans
MH  - Mice
MH  - Mice, Nude
MH  - Protein Isoforms
MH  - RNA, Messenger/biosynthesis/genetics
MH  - S-Phase Kinase-Associated Proteins/metabolism
MH  - Transplantation, Heterologous
EDAT- 2006/04/06 09:00
MHDA- 2006/05/23 09:00
CRDT- 2006/04/06 09:00
PHST- 2006/04/06 09:00 [pubmed]
PHST- 2006/05/23 09:00 [medline]
PHST- 2006/04/06 09:00 [entrez]
AID - 66/7/3593 [pii]
AID - 10.1158/0008-5472.CAN-05-2912 [doi]
PST - ppublish
SO  - Cancer Res. 2006 Apr 1;66(7):3593-602. doi: 10.1158/0008-5472.CAN-05-2912.